1. 冠心病抗血小板个体化治疗 Individualized anti-platelet therapy in coronary heart disease2. 心肌纤维化时lncRNA的分子调控 Long non-coding RNA modulation of myocardial fibrosis after myocardial infarction
本人近年来进行了抗血小板药物的个体化治疗和基因多态性、腺苷敏感性钾通道的电生理特性、空气污染对AMI发病率的影响、microRNA-15b对心肌缺血再灌注损伤影响的研究。申请到上海市浦东新区卫计委面上科研项目1项，上海市科委西医引导项目1项，发表SCI论文11篇，中文核心期刊论著3篇，综述4篇。将在长链非编码RNA（lncRNA）对心肌梗死后纤维化方面进行进一步研究，形成了以冠心病抗血小板治疗和心肌梗死后心力衰竭为主的科研体系。
Research projects have been carried out in several fields such as individualized anti-platelet therapy and gene polymorphism, the electrophysiological characteristics of adenosine sensitive potassium channel and the effect of air pollution on the incidence of AMI. The Grant from The Shanghai Pudong New Area health and Family Planning Commission and The Science and Technology Commission of Shanghai Municipality have been successfully applied for. The further study will be conducted on long non-coding RNA modulation of myocardial fibrosis after myocardial infarction.
发表论文：1. Yaling Liu,1 Liqun Yang,1 Jiemin Yin,1 Diansan Su,1 Zhiying Pan,1 Peiying Li,Xiaodong Wang. MicroRNA-15b deteriorates hypoxia/reoxygenation-induced cardiomyocyte apoptosis by downregulating Bcl-2 and MAPK3. Accepted. J Investig Med 2017;0:1–7. doi:10.1136/jim-2017-000485.
2. Xiaodong Wang, Yan Lai, Yu Luo, Xumin Zhang, Hua Zhou. Relationship between clopidogrel-related polymorphisms and variable platelet reactivity at 1 year: A cohort study from Han Chinese. J Res Med Sci. 2016 Nov 7;21:111. (IF: 0.812)
3. Wang XD, Zhang XM, Zhuang SW, Luo Y, Kang S, Liu YL. Short-term effects of air pollution on acute myocardial infarctions in Shanghai, China, 2013–2014. J Geriatr Cardiol. 2016 Feb;13(2):132-7. (IF: 1.393)
4. Zhang X, Wang X (co-first author), Zhou X, Ma X, Yao Y, Liu X. Phenotypic transformation of smooth muscle cells from porcine coronary arteries is associated with connexin 43. Mol Med Rep. 2016 Jul;14(1):41-8. (IF: 1.559)
5. Luo Y, Tang J, Liu X, Qiu J, Ye Z, Lai Y, Yao Y, Li J, Wang X, Liu X. Coronary Artery Aneurysm Differs From Coronary Artery Ectasia: Angiographic Characteristics and Cardiovascular Risk Factor Analysis in Patients Referred for Coronary Angiography. Angiology. 2016 Aug 27. [Epub ahead of print] (IF: 2.931)
6. Skibsbye L, Wang X, Axelsen LN, Bomholtz SH, Nielsen MS, Grunnet M, Bentzen BH, Jespersen T. Antiarrhythmic mechanisms of SK channel inhibition in the rat atrium. J Cardiovasc Pharmacol. 2015 Aug;66(2):165-76. (IF: 2.462)
7. Luo Y, Wang X, Ye Z, Lai Y, Yao Y, Li J, Liu X. Remedial hydration reduces the incidence of contrast-induced nephropathy and short-term adverse events in patients with ST-segment elevation myocardial infarction: a single center, randomized trail. Intern Med. 2014;53(20):2265-72. (IF: 0.832)
8. Liang B, Nissen JD, Laursen M, Wang X, Skibsbye L, Hearing MC, Andersen MN, Rasmussen HB, Wickman K, Grunnet M, Olesen SP, Jespersen T. G-protein coupled inward rectifier potassium current contributes to ventricular repolarization. Cardiovasc Res. 2014 Jan 1;101(1):175-84. (IF: 5.465)
9. Wang X, Liang B, Skibsbye L, Olesen SP, Grunnet M, Jespersen T. GIRK channel activation via adenosine or muscarinic receptors has similar effects on rat atrial electrophysiology. J Cardiovasc Pharmacol. 2013 Aug;62(2):192-8. (IF: 2.462)
10. Wang XD, Zhang DF, Liu XB, Lai Y, Qi WG, Luo Y, Hu B, Yao YA. Modified clopidogrel loading dose according to platelet reactivity monitoring in patients carrying ABCB1 variant alleles in patients with clopidogrel resistance. Eur J Intern Med. 2012 Jan;23(1):48-53. (IF: 2.431)
11. Wang XD, Zhang DF, Zhuang SW, Lai Y. Modifying clopidogrel maintenance doses according to vasodilator-stimulated phosphoprotein phosphorylation index improves clinical outcome in patients with clopidogrel resistance. Clin Cardiol. 2011 May;34(5):332-8. (IF: 2.591)
12. 王小东，周华，张旭敏，胡铂，刘亚玲。氨茶碱对冠心病患者使用替格瑞洛致呼吸困难的干预研究。临床心血管病杂志，2017，33（5）：427-430。
13. 王小东，庄少伟，张旭敏，周华，来晏，康晟，夏光，周建，刘学波。替格瑞洛对老年急性心肌梗死患者血小板功能及临床预后的影响。国际心血管病杂志，2016，43（3）：183-186。
14. 王小东，刘学波。 急性冠脉综合征新型抗凝药物研究进展。国际心血管病杂志，2015，42（1）：6-9。
15. 王小东，刘学波。经皮冠状动脉介入治疗围术期抗凝药物应用研究进展。中国介入心脏病学杂志，2014，22（11）：729-31。
16. 王小东，张代富。血小板功能及抗血小板药物疗效检测研究进展。5848vip威尼斯电子游戏学报，2011，32（4）：120-4。
17. 王小东，张代富。MicroRNAs与心肌梗死研究进展。心血管病学进展，2011，32（2）：171-5。
18. 王小东，李培杰，杨兰等。乌司他丁对家兔心肺复苏后心脏保护作用的实验研究。乌司他丁对家兔心肺复苏后心脏保护作用的实验研究，2007，（27）5：436-9。
主持课题：1. 项目名称：房颤患者冠脉支架术后抗血小板治疗的个体化方案研究
项目类别：面上项目
项目编号：PW2014A-16
2. 项目名称：房颤患者冠脉支架术后华法林联合新型抗血小板药物替格瑞洛的个体化方案研究
项目类别：西医引导类
参与课题：谭红伟，2013年国家自然科学基金青年基金：类胰蛋白酶激活心房成纤维细胞的机制研究。项目批准号：81300136
