从海洋生物中快速发现结构新颖的活性化合物、先导化合物的结构优化、药理活性及作用机制研究，获得具有药用价值的生物新资源及药物先导化合物；药品、功能性食品新资源的筛选和创新天然药物的研究开发。

Study on the rapid discovery of novel biological active compounds from natural products in marine orgnisms, and optimizing lead compounds structure, screening their pharmacological activities and mechanism of action.Thus we could obtain drug lead compounds and new biological resources with medicinal value; developing drugs, functional food resources and innovative natural medicine research.

上海药学会海洋药物专业委员会委员
中国生物化学与分子生物学学会海洋生物化学与分子生物学分会委员会理事
《Natural Product Research》等审稿人

主持和参加项目
1. 2020.11 - 2021.11，MIMP蛋白及其衍生物的药效学研究（150020210069），主持，在研
2. 2019.12 - 2021.11，中药新药软坚清脉颗粒治疗下肢动脉闭塞症的临床前研究（150020200017），主持，在研
3. 2019.7-2021.6 重点研发计划（深海关键技术与装备）（SQ2019YFC030362/02）深海药源天然产物的生物合成路径改造和结构优化，课题骨干，在研
4. 2018.7-2019.7，间充质干细胞治疗疾病的初步药学研究，主持，结题
5. 2018.3-2019.7，医用透明质酸钠抗肿瘤作用的研究，主持，结题
6. 2018.3-2019.10，人纤维蛋白粘合剂临床前药理研究，主持，结题
7. 2018.7-2019.7，医用透明质酸钠对细菌生长及抗生素作用的影响研究，主持，结题
8. 2017.7-2021.12，天然多糖类等产品对抑制细胞迁移的影响研究，主持，在研

已在国内、外刊物发表论文50余篇。其中，30余篇研究成果发表在在专业核心SCI期刊，论文多次被引用；获国家授权专利3项。

发表论文（SCI）：
1. Chen XW, Lu DY, Li ZH, Yue WC, Wang J, Jiang XY, Han H*, Wang CH. Plant and Animal-Type Feedstuff Shape the Gut Microbiota and Metabolic Prosesses of the Chinese Mitten Crab Eriocheir sinensis. Frontiers in Veterinary Science, 2021, 1(26) doi: 10.3389/fvets. 2021.589624.
2. Yang WS, Qi XR, Xu QZ, Yuan CH, Yi YH, Tang HF, Shen L, Han H * A New Sulfated Triterpene Glycoside from the Sea Cucumber Colochirus quadrangularis, and Evaluation of Its Antifungal, Antitumor and Immunomodulatory Activities. Bioorganic & Medicinal Chemistry, 2021
3. Shen NN, Zhang C, Wang N, Wang JL, Gu ZC, Han H *. Effectiveness and Safety of Under or Over-dosing of Direct Oral Anticoagulants in Atrial Fibrillation: A Systematic Review and Meta-analysis of 148909 Patients From 10 Real-World Studies. Frontiers in Pharmacology. 2021.
4. Yang F , Gao Y, Chang YT, Zou YK , Houk KN , Lu JR , He J , Tang WZ , Liao HZ , Han H* , Lin HW . Aromatic Ring Substituted Aaptamine Analogues as Potential Cytotoxic Agents against Extranodal Natural Killer/T-Cell Lymphoma. J Nat Prod. 2020, 83(12): 3758-3763.
5. Tang WZ, Liu JT, Hu Q, He RJ, Guan XQ, Ge GB, Han H, Yang F, Lin HW. Pancreatic Lipase Inhibitory Cyclohexapeptides from the Marine Sponge-Derived Fungus Aspergillus sp. 151304. J. Nat. Prod. 2020, 83, 7, 2287–2293.
6. Lv QZ, Li DD , Han H, Yang YH , Duan JL , Ma HH , Yu Y , Chen JY , Jiang YY, Jia XM . Priming with FLO8-deficient Candida albicansinduces Th1-biased protective immunity against lethal polymicrobial sepsis. Cell Mol Immunol., 2020, 5: 1-14.
7. Hou X, Chen XW, Yang H, Yue WC, Wang J, Han H *, Wang CH. V-ATPase subunit B plays essential roles in the molting process of Chinese mitten crab, Eriocheir sinensis. Biology Open, 2020, 9(5): DOI:10.1242/bio.048926.
8. Jiao FR, Gu BB, Zhu HR, Zhang Y, Liu KC, Zhang W, Han H *, Xu SH, Lin HW. Asperfloketals A and B, the First Two Ergostanes with Rearranged A and D Rings: from the Sponge-Associated Aspergillus flocculosus 16D-1. The Journal of Organic Chemistry, 2020, DOI: 10.1021/acs.joc.0c02049
9. Yue WC, Yang H, Chen YP, Wang J, Chen XW, Hou X, Han H*, Wang CH. RNA interference provides insights into the multi-functional profiles of Es-MSTN gene in Eriocheir sinensis. Aquaculture Reports, 2020, 17: 100310-100317. ( IF=2.289)
10. Xu QQ, Shi WW, Lv P, Meng WQ, Mao GC, Gong CC, Chen YC, Wei YH, He XW, Zhao J, Han H *, Mingxue Sun and Kai Xiao. Critical role of caveolin-1 in aflatoxin-1 in aflatoxin B1-induced hepatotoxicity via the regulation of oxidation and autophagy[J]. Cell Death & Disease, 2020, 11(1): 1-16. https://doi.org/10.1038/s41419-019-2197-6)
11. Huang HR , Li F, Han H , Xu X , Li N , Wang SC, Xu JF, Jia XM . Dectin-3 Recognizes Glucuronoxylomannan of Cryptococcus neoformans Serotype AD and Cryptococcus gattii Serotype B to Initiate Host Defense Against Cryptococcosis[J]. Frontier in Immunology, 2018, 9:1781-1788.
12. Kang JX, Kang YF, Han H*. Three new cytotoxic polyhydroxysteroidal glycosides from starfis Craspidaster Hesperus[J]. Marine drugs, 2016, 14(10): 189-199.