亮点介绍：
长期致力于纳米递药系统研究，聚焦递药系统的三大关键科学问题（递送、释放、干预），运用生物启发及整合生物学思想，创新递药策略，并重点探索创新策略在免疫调控领域的应用。整合免疫细胞的生物特性，发展活细胞二硫键工程，在粒细胞通过ROS 杀伤的天然机制之上，内置人工ROS 发生器，大幅提高粒细胞的肿瘤杀伤性能（Cell Reports, 2020）；整合肿瘤细胞的生物特性，发展光动力增强的疫苗新技术 （Biomaterials, 2020, 244, 119964），在基于肿瘤细胞膜包覆技术的纳米疫苗上取得阶段性进展；启发于病毒的多价效应，发展“minimalisit”纳米疫苗新理念 (ACS Nano, 2018, 12, 6398)，ACS Nano 同期以“Less is More for Cancer Nanovaccine”为题对该工作进行图文介绍 (ACS Nano 2018, 12, 6347)；启发与发烧的免疫刺激作用，发展“类发烧”免疫治疗技术(Advanced Science. 2018;1700805)。国际期刊Immunotherapy 邀请领域专家对该工作进行专题评论 (Immunotherapy 2018，10, 631)。已正式发表一作或通讯SCI 论文80 余篇，包括Advanced Materials (IF：30.849)，ACS Nano (IF：15.881)，Advanced Science (IF：16.806)，Biomaterials （IF: 12.479），Small （IF：13.28），ACS AMI （IF：9.2）等期刊。论文他引总计3000 余次，H index 36。合作编著《Methods in Molecular biology, with the topic of siRNA delivery methods》，《Nanomaterials for Tumor Targeting Theranostics》及全国高等教育药学类规划教材《分子生物药剂学》。
主持项目：
上海市卫生健康学科带头人 （2022.7~2025.6）
国家自然科学基金面上项目（2018-2021）
5848vip威尼斯电子游戏青年百人计划（2017~2019）；
国家自然科学基金面上项目（2015-2018）；
上海市青年科技启明星计划（2012-2014）
国家自然科学基金面上项目（2012-2015）
国家自然科学青年基金（2011-2013）；
上海市晨光计划（2011-2013）；
上海市自然科学基金（2010-2012）
重大项目参与：
科技创新2030—“脑科学与类脑研究〞重大项目脑计划子课题：焦虑障碍的发病机制和干预技术研究（2021.12 ~2026.12），负责焦虑药物的微针剂型设计与构建。（80万）
国家重大科学研究计划, 项目名称：干细胞治疗视网膜变性的基础与临床转化研究（起止时间：2013.01~2017.12），负责干细胞递送系统设计与构建。 （80万）
代表性论文：
1. Yiqiong Liu, Ying Liu, Dailin Xu, Jie Zang, Xiao Zheng, Yuge Zhao, Yan Li, Ruiqing He, Shuangrong Ruan, Haiqing Dong, Jingjing Gu, Yan Yang, Qian Cheng, and Yongyong Li*，Targeting the Negative Feedback of Adenosine-A2AR Metabolic Pathway by a Tailored Nanoinhibitor for Photothermal Immunotherapy，Adv. Sci. 2022, 2104182 （IF 17.521）
2. Yiqiong Liu, Dailin Xu, Ying Liu, Xiao Zheng, Jie Zang, Wanli Ye, Yuge Zhao, Ruiqing He, Shuangrong Ruan, Tingting Zhang, Haiqing Dong, Yan Li, Yongyong Li *，Remotely boosting hyaluronidase activity to normalize the hypoxic immunosuppressive tumor microenvironment for photothermal immunotherapy，Biomaterials，2022，284，121516 （IF 15.304）
3. Jie Zang, Ruiqing He, Yiqiong Liu, Runping Su, Yuge Zhao, Xiao Zheng, Ying Liu, Gaowei Chong, Shuangrong Ruan, Huaiji Wang, Dailin Xu, Haiqing Dong, Yongyong Li *，A size/charge/targeting changeable nano-booster to realize synergistic photodynamic-immunotherapy with high safety，Chemical Engineering Journal，2022，434，13485 （IF 16.744）
4. Yi Han 1 , Yanchao Liu 1 , Xiaoyi Ma, Aijun Shen, Yiqiong Liu, Nopphon Weeranoppanant, Haiqing Dong, Yan Li, Tianbin Ren, Le Kuai, Bin Li*, Maomao An*, Yongyong Li*, Antibiotics armed neutrophils as a potential therapy for brain fungal infection caused by chemotherapy- induced neutropenia,Biomaterials,2021,274,120849. (IF=15.304)
5. Huaiji Wang, Ying Liu,Ruiqing He,Dailin Xu,Jie Zang,Nopphon Weeranoppanant,Haiqing Dong* and Yongyong Li*, Cell membrane biomimetic nanoparticles for inflammation and cancer targeting in drug delivery, Biomaterials Science, 2020, 8, 552–568 (IF=7.59) ESI高被引论文
6. Yan Li,* Yi Han, Runping Su, Yiqiong Liu, Gaowei Chong, Dailin Xu, Ruiqing He, Ying Liu, Haiqing Dong, Donglu Shi, and Yongyong Li*, Photosensitizer-Laden Neutrophils Are Controlled Remotely for Cancer Immunotherapy, Cell Reports, 2020, 33, 108499 (IF=9.995)
7. Huaiji Wang, Kun Wang, Lianghua He, Ying Liu, Haiqing Dong*, Yongyong Li*, Engineering antigen as photosensitiser nanocarrier to facilitate ROS triggered immune cascade for photodynamic immunotherapy, Biomaterials, 2020, 244, 119964 (IF=15.304)
8. CongyuWu, Yajing Shen Y, Mengwei Chen, Kun Wang, Yongyong Li*, Yu Cheng*. Recent Advances in Magnetic-Nanomaterial-Based Mechanotransduction for Cell Fate Regulation, Advanced Materials, 2018, 30, 1705673. (IF=32.086) 邀请综述
9. Yan Li, Lianghua He, Haiqing Dong, Yiqiong Liu, Kun Wang, Ang Li, TianbinRen, Donglu Shi, Yongyong Li*. Fever-inspired Immunotherapy Based on Photothermal CpG Nanotherapeutics: The Critical Role of Mild Heat in Regulating Tumor Microenvironment, 2018，Adv. Sci.，5, 1700805 (IF=17.521)
10. Kun Wang, Shuman Wen, Lianghua He, Ang Li, Yan Li, Haiqing Dong, Wei Li, Tianbin Ren, Donglu Shi, Yongyong Li*. ‘Minimalist’ Nanovaccine Constituted with Near Whole Antigen for Potent Cancer Immunotherapy, 2018, ACS Nano,12, 6398-6409. (IF=18.027)
11. Haiqing Dong, Yongyong Li*, Jin Yu, Yanyan Song, Xiaojun Cai, Jiaqiang Liu, Jiaming Zhang, RC Ewing, Donglu Shi*, A Versatile Multi-Component Assembly via β-cyclodextrin Host-Guest Chemistry on Graphene for Biomedical Applications, Small, 2013, 9,446-456. (IF=15.153)
12. Hui-Yun Wen, Chunyan Dong, Haiqing Dong, Aijun Shen, Wenjuan Xia, Xiaojun Cai, Yanyan Song, Xuequan Li, Yongyong Li* and Donglu Shi, Engineered Redox-Responsive PEG Detachment Mechanism in PEGylated Nano-graphene Oxide for Intracellular Drug Delivery, Small, 2012, 8, 760-769. ESI高被引论文
13. Hui-Yun Wen, Hai-Qing Dong, Wen-juan Xie, Yongyong Li*, Kang Wang, Giovanni M. Pauletti and Dong-Lu Shi, Rapidly disassembling nanomicelles with disulfide-linked PEG shells for glutathione-mediated intracellular drug delivery. Chem. Commun., 2011, 47, 3550-3552. ESI高被引论文
