1. 美国神经科学学会“女性神经科学家理事会”、“职业发展理事会”理事
2. 戈登会议分子细胞神经生物学会议副主席(2014)/主席(2016)
3. 中国干细胞再生医学专业委员会常务委员
4. 中国干细胞产业联盟理事会专家委员会委员
5. 中国整形美容协会干细胞研究与应用分会理事会常务理事
6. Cells期刊编委
1. Member, Committee on Women in Neuroscience, Society for Neuroscience (SfN-WIN);
Member, Professional Development Committe, Society for Neuroscience (SfN-PDC)
2. Vice Chair, Gordon Research Conference (GRC), Molecular & Cellular Neurobiology (2014);
Chair, Gordon Research Conference (GRC), Molecular & Cellular Neurobiology (2016)
3. Member, Standing Committee of China Stem Cell Regenerative Medicine Professional Committee
4. Member, Standing Committee of Expert Committee of China Stem Cell Industry Alliance Council
5. Member, Standing Committee of the Council of Stem Cell Research and Application Branch of China Plastic and Aesthetic Association
6. Member, Editorial Board of Cells journal
在神经干细胞分化及表观遗传调控领域成果卓著,发表了多篇Cell,Nature,Science文章;在自闭症谱系病Rett综合征研究领域独树一帜,不仅对MECP2基因在神经干细胞中的功能,以及通过人源多能干细胞建立疾病模型方面成就不断,并且在全球首次成功利用基因编辑技术建立了表型酷似人类疾病的非人灵长类Rett综合征模型,相关工作发表于Cell、Cell Stem Cell;首次通过单细胞测序发现室管膜静息态成体神经干细胞,发表于Cell;通过结合生物材料促进中枢神经系统再生,揭示了中枢神经系统修复的底层逻辑,即抑制损伤区域炎性微环境,激活内源性神经干细胞产生新生神经元,继而形成“中继站”网络整合入受损神经环路,通过神经可塑性开辟新的神经信号传递通路进而恢复功能;指出外周免疫大环境与中枢免疫微环境相互影响,并显著调控神经传导功能及神经干细胞的再生修复潜能,同时提出血脑通讯是中枢神经系统疾病修复中神经免疫互作的桥梁,相关研究成果发表于多篇PNAS。曾获美国斯隆研究奖,贝克曼青年研究者奖,白厅基金会研究奖,斯坦-奥本海默奖,克林根斯坦神经生物学研究奖,上海市科学技术-国际合作奖等。先后发表SCI论文118篇,总影响因子超过2000,H指数为64,被引频次共计22158次。
Yi Eve Sun has made outstanding achievements in the field of neural stem cell differentiation and epigenetic regulation, and has published many articles in journals including Cell, Nature, and Science; She is unique in the field of research on an autism spectrum disorder (Rett syndrome, RTT), not only on the function of MECP2 gene in neural stem cells, but also have made continuous achievements in establishing disease models via human-derived pluripotent stem cells, and for the first time in the world, she and collaborators have successfully used gene editing technology to establish a non-human RTT model with a phenotype similar to human patients. Related work was published in Cell, Cell Stem Cell. The ependymal quiescent adult neural stem cells were discovered for the first time by single cell sequencing, published in Cell. By combining biomaterials to promote central nervous system regeneration, the underlying logic of central nervous system repair was revealed, that is, to inhibit the inflammatory microenvironment in the damaged area, activate endogenous neural stem cells to generate new neurons, and then form nascent relay network to integrate into broken circuits to resume neural function via neural plasticity; She also pointed out that the peripheral immune environment and the central immune microenvironment interact with each other, and significantly regulate the nerve conduction function and the regenerative repair potential of neural stem cells. At the same time, it is proposed that blood-brain communication is the bridge of neuroimmune interaction in the repair of central nervous system diseases. Related research results have been published in many PNAS articles. She has won the Alfred P. Sloan Research Fellow, the Beckman Young Investigator Award, the Whitehall Foundation Research Award, the Stein-Oppenheimer Endowment Award, the Klingenstein Neuroscience Research Award, and the Shanghai Science and Technology-International Cooperation Award, etc. She has published 118 SCI papers, with a total impact factor of more than 2000, an H index of 64, and a total of 22,158 citations.