一、代表性论文:
Yu Y, Wang RR, Miao NJ, Tang JJ, Zhang YW, Lu XR, Yan PY, Wang J, Jia XM*. PD-L1 negatively regulates antifungal immunity by inhibiting neutrophil release from bone marrow. Nat Commun. 2022 Nov 11;13(1):6857. (*Corresponding author)
Li YN, Wang ZW, Li F, Zhou LH, Jiang YS, Yu Y, Ma HH, Zhu LP, Qu JM*, Jia XM*. Inhibition of myeloid-derived suppressor cell arginase-1 production enhances T-cell-based immunotherapy against Cryptococcus neoformans infection. Nat Commun. 2022 Jul 14;13(1):4074. (*Corresponding author)
Duan JL, He HQ, Yu Y, Liu T, Ma SJ, Li F, Jiang YS, Lin X, Li DD, Lv QZ, Ma HH, Jia XM*. E3 ligase c-Cbl regulates intestinal inflammation through suppressing fungi-induced noncanonical NF-κB activation. Sci Adv. 2021 May 7(19): eabe5171. (*Corresponding author).
Lv QZ, Li DD, Han H, Yang YH, Duan JL, Ma HH, Yu Y, Chen JY, Jiang YY*, Jia XM*. Priming with FLO8-deficient Candida albicans induces Th1-biased protective immunity against lethal polymicrobial sepsis. Cell Mol Immunol. 2021 Aug;18(8):2010-2023. (*Corresponding author)
Wang W, Ding CL, Wu MX, Guo W, Hu R, Liu Y, Qi ZT, Jia XM*. RAI16 maintains intestinal homeostasis and inhibits NLRP3-dependent IL-18/CXCL16-induced colitis and the progression of colitis-associated colorectal cancer. Clin Transl Med. 2022 Aug;12(8):e993. (*Corresponding author)
Jiang Y, Li F, Li Y, Duan J, Di C, Zhu Y, Zhao J, Jia X*, Qu J*. CD69 mediates the protective role of adipose tissue-derived mesenchymal stem cells against Pseudomonas aeruginosa pulmonary infection. Clin Transl Med. 2021 Nov;11(11): e563. (*Corresponding author)
Xu X; Xu JF; Zheng G; Lu HW; Duan JL; Rui W; Guan JH; Cheng LQ; Yang DD; Wang MC; Lv QZ; Li JX; Zhao X; Chen CX; Shi P; Jia XM*; Lin X*, CARD9S12N facilitates the production of IL-5 by alveolar macrophages for the induction of type 2 immune responses. Nat Immunol. 2018 Jun;19(6):547-560. (*Corresponding author)
Zhu LL, Luo TM, Xu X, Guo YH, Zhao XQ, Tang B, Jiang YY, Lin X*, Jia XM*. E3-ubiquitin-ligase Cbl-b negatively regulates C-type lectin receptor-mediated anti-fungal innate immunity. J Exp Med. 2016 Jul 25;213(8):1555-70. (*Corresponding author)
Jia XM*, Tang B, Zhu LL, Zhao XQ, Gorjestani S, Hsu YS, Xu GT, Lin X*. CARD9 mediates Dectin-1-induced ERK activation by linking Ras-GRF1 to H-Ras for anti-fungal immunity. J Exp Med. 2014 Oct 20; 211(11):2307-21. (*Corresponding author)
Zhu LL, Zhao XQ, Jiang C, You Y, Chen XP, Jiang YY, Jia XM*, Lin X*. C-Type Lectin Receptors Dectin-3 and Dectin-2 Form a Heterodimeric Pattern-Recognition Receptor for Host Defense against Fungal Infection. Immunity, 2013 Aug 22, 39(2): 324–334. (*Corresponding author, recomended by Faculty of 1000)
Zhao XQ, Zhu LL, Chang Q, Jiang C, You Y, Jia XM*, Lin X*. C-type lectin receptor Dectin-3 mediates trehalose 6,6‘-dimycolate (TDM)-induced Mincle expression through CARD9/Bcl10/MALT1-dependent NF-ĸB activation. J Biol Chem. 2014; 289(43):30052-62. (*Corresponding author)
二、承担基金汇总:
国家自然科学基金,面上项目,82371777,B细胞连接蛋白BLNK抑制巨噬细胞迁移负调抗真菌免疫的作用及机制研究,2024/01-2027/12,51万元,在研,主持;
国家重点研发计划,2022YFC2303004,宿主免疫应答机理与真菌防控策略研究,2022/12-2025/11,137万元,在研,子课题负责人;
国家重点研发计划,2021YFC2300403,重要真菌病原体的环境适应及宿主侵染机制研究,2021/12-2024/11,105万元,在研,课题骨干;
国家自然科学基金,面上项目,31970889,天然免疫细胞中接头蛋白CARD9先天性变异抑制IL-10表达促进炎症性肠病发生的作用及机制研究,2020/01-2023/12,58万元,在研,主持;
国家自然科学基金,优秀青年科学基金项目,31622023,C型凝集素受体介导宿主抗真菌感染的固有免疫应答,2017/01-2019/12,130万元,结题,主持;
国家自然科学基金,面上项目,81571611,CARD9基因缺陷导致变态反应性支气管肺曲霉菌病的基础和临床研究,2016/01-2019/12,54万元,结题,主持;
上海市卫健委卫生行业临床研究专项(卓越项目),20224Z0020,免疫球蛋白超家族受体AGER突变介导宿主抗真菌感染免疫的基础与临床研究,2022/01-2024/12,50万元,在研,主持;
上海市教委科研创新计划自然科学重大项目,201901070007E00022,转录因子Flo8调控白念珠菌表面甘露聚糖结构修饰发挥抗真菌免疫保护机制研究,2019/01-2023/12,300万元,在研,主持;
上海市科委基础研究重点基金,20JC1417700,靶向PD-L1促进成熟中性粒细胞向肾脏迁移抗白念珠菌感染的作用及分子机制,2020/10-2023/12,80万元,在研,主持;
上海市科委实验动物专项,21140903300,构建髓样细胞中Clec2d基因条件敲除小鼠研究肺隐球菌感染免疫逃逸机制,2021/6-2024/6,25万元,在研,主持。
上海市卫计委优秀学术带头人,2017BR024,隐球菌感染的固有免疫识别及应答机制研究,2017/09-2020/12,45万元,结题,主持;