课题组围绕衰老与心血管疾病开展跨学科交叉的基础与转化研究，主要包括：
1.基于干细胞与组织工程的器官修复；
2.细胞外囊泡的信息递送与工程化改造；
3.单细胞组学技术；

Interdisciplinary studies for aging and cardiovascular disease, including:
1, Stem cell and tissue engineering;
2, Extracellular vesicle；
3, Single-cell omics

上海市科学技术奖评审专家（上海市科委，2019）
"Academic Journal Reviewer" (Theranostics、Stem cells、BBA - Molecular Basis of Disease);

2014年获理学博士学位，复旦大学-哈佛大学联合培养，师从著名心血管病学专家-中国科学院院士葛均波教授。课题组整合干细胞与组织工程、细胞外囊泡以及单细胞组学技术，针对衰老以及心血管疾病的病理机制和防治策略，开展跨学科交叉的基础与转化研究，并获得了一系列成果。相关论文以通讯或第一作者身份发表于Protein Cell、Theranostics、ATVB等高水平期刊上；主持国家自然科学基金2项，省部级课题3项。
代表性论文如下：

1. Yiteng Liao, Hao Li, Hao Cao, Yun Dong, Lei Gao, Zhongmin Liu, Junbo Ge, Hongming Zhu (通讯作者). Therapeutic silencing miR-146b-5p improves cardiac remodeling in a porcine model of myocardial infarction by modulating the wound reparative phenotype. Protein Cell. 2021,12(3):192-212. (IF:14.87)

2. Lei Gao, Hongjie Zhang, Jingyi Cui, Lijuan Pei, Shiqi Huang, Yaning Mao, Zhongmin Liu, Ke Wei, Hongming Zhu (通讯作者). Single-cell transcriptomics of cardiac progenitors reveals functional subpopulations and their cooperative crosstalk in cardiac repair. Protein Cell. 2021, 12(2):152-157. (IF: 14.87)

3. Lei Gao, Shuya Mei, Shuning Zhang, Qing Qin, Hao Li, Yiteng Liao, Huimin Fan, Zhongmin Liu, Hongming Zhu (通讯作者). Cardio-renal Exosomes in Myocardial Infarction Serum Regulate Proangiogenic Paracrine Signaling in Adipose Mesenchymal Stem Cells. Theranostics. 2020; 10(3): 1060-1073. (IF: 11.56)

4. Hao Li, Yiteng Liao, Lei Gao, Tao Zhuang, Zheyong Huang, Hongming Zhu (通讯作者), Junbo Ge. Coronary Serum Exosomes Derived from Patients with Myocardial Ischemia Regulate Angiogenesis through the miR-939-mediated Nitric Oxide Signaling Pathway. Theranostics. 2018; 8(8): 2079-2093. (IF: 11.56)

5. Lei Gao, Hongming Zhu (通讯作者), Huimin Fan, Zhongmin Liu. Chloroquine exacerbates serum withdrawal-induced G1 phase arrest via an autophagy-independent mechanism. RSC Advances, 2017, 7, 46082-46091. (IF: 3.36)

6. Hongming Zhu（第一作者）, Aijun Sun, Yunzeng Zou, Junbo Ge. Inducible Metabolic Adaptation Promotes Mesenchymal Stem Cell Therapy for Ischemia: A Hypoxia-Induced and Glycogen-Based Energy Prestorage Strategy. Arteriosclerosis, Thrombosis, and Vascular Biology. 2014; 34: 894-901. (IF: 8.31)

7. Hongming Zhu（第一作者）, Aijun Sun, Hong Zhu, Zheng Li, Zheyong Huang, Shuning Zhang, Xin Ma, Yunzeng Zou, Kai Hu and Junbo Ge. Aldehyde Dehydrogenase-2 Is a Host Factor Required for Effective Bone Marrow Mesenchymal Stem Cell Therapy. Arteriosclerosis, Thrombosis, and Vascular Biology. 2014; 34: 870-876. (IF: 8.31)

8. Cheng Shen, Cong Wang, Shasha Han, Zhenjun Wang, Zhen Dong, Xiaona Zhao, Peng Wang, Hong Zhu, Xiaolei Sun, Xin Ma, Hongming Zhu (通讯作者), Yunzeng Zou, Kai Hu, Junbo Ge, Aijun Sun. Aldehyde Dehydrogenase 2 Deficiency Negates Chronic Low-to-Moderate Alcohol Consumption-induced Cardioprotecion Possibly via ROS-dependent Apoptosis and RIP1/RIP3/MLKL-mediated Necroptosis. BBA Molecular Basis of Disease.2016; (16)30298-8 （IF: 5.19）

9. Hao Li, Hongming Zhu (通讯作者), Junbo Ge. Long Noncoding RNA: Recent Updates in Atherosclerosis. International Journal of Biological Sciences. 2016; 12: 898-910（IF:6.58）