5848vip威尼斯电子游戏预聘助理教授（Assistant professor, School of Medicine, Tongji University）
主要学术成绩：
以斑马鱼和鼠为动物模型，聚焦研究脊髓损伤后脊髓中间神经元轴突再生和运动神经环路重建的内源机制。解析了脊髓损伤后脊髓内源性5-HT神经元通过靶向5-HT1B受体促进脊髓兴奋性中间神经元轴突再生和运动神经环路重建的内源机制（Nature Communications，2021）；进一步揭示了脊髓V2a中间神经元轴突再生规律和对运动功能恢复的决定性作用（Cell Reports，2022）。上述研究为脊髓损伤临床治疗提供了新的依据和策略。以第一作者身份发表数篇高质量论文，主持国家自然科学基金青年科学基金项目。入选2022年普陀区青年英才。
Focus on axon regrowth of spinal interneuron and spinal circuit reestablishment after spinal cord injury (SCI) using zebrafish and mouse model. Described an intraspinal mechanism that an injury-induced subpopulation of intraspinal serotonergic neurons stimulates axon regrowth of spinal excitatory interneurons and spinal circuit reestablishment by targeting 5-HT1B receptor (Nature Communications，2021). Further revealed a principle governing the axon regrowth of V2a interneurons which play critical roles in locomotor recovery (Cell Reports, 2022). These findings reveal the pathophysiological mechanisms of neural control of locomotor recovery after SCI and shed light on clinical therapy.
代表性论文：
Huang CX#, Wang Z, Cheng J, Zhu Z, Guan NN, Song J. De novo establishment of circuit modules restores locomotion after spinal cord injury in adult zebrafish. Cell Rep. 2022 Oct 25;41(4):111535.
Huang CX, Zhao Y, Mao J, Wang Z, Xu L, Cheng J, Guan NN, Song J. An injury-induced serotonergic neuron subpopulation contributes to axon regrowth and function restoration after spinal cord injury in zebrafish. Nat Commun. 2021 Dec 7;12(1):7093.
Huang CX#, Huang Y#, Duan XK, Zhang M, Tu JP, Liu JX, Liu H, Chen TS, Wang WM, Wang HL. Zebrafish miR-462-731 regulates hematopoietic specification and pu.1-dependent primitive myelopoiesis. Cell Death Differ. 2019 Aug; 26(8): 1531-1544.
Huang CX, Chen N, Wu XJ, Huang CH, He Y, Tang, R, Wang WM, Wang HL. The zebrafish miR-462/miR-731 cluster is induced under hypoxic stress via hypoxia-inducible factor 1α and functions in cellular adaptations. FASEB J. 2015 Dec; 29(12): 4901-4913.
Guan NN, Xu L, Zhang T, Huang CX, Wang Z, Dahlberg E, Wang H, Wang F, Pallucchi I, Hua Y, El Manira A, Song J. A specialized spinal circuit for command amplification and directionality during escape behavior. Proc Natl Acad Sci U S A. 2021 Oct 19;118(42):e2106785118.
Xu L, Guan NN, Huang CX, Hua Y, Song J. A neuronal circuit that generates the temporal motor sequence for the defensive response in zebrafish larvae. Curr Biol. 2021 Aug 9;31(15):3343-3357.e4.
