主持和参与国家自然科学基金项目3项。
主持国家自然科学基金面上项目一项：
高甘油三酯血症相关性急性胰腺炎中游离脂肪酸对JAK2/STAT3 通路的影响。项目批准号： 81270546。
参与国家自然科学基金2项：
胆汁淤积通过胆汁酸受体GpBAR1途径致肠道动力障碍的机制。
批准号：81100257。
LKB1/AMPK调整有氧酵解信号途径诱导结肠癌细胞凋亡机制的研究。批准号：81272745.
以第一作者或通讯作者发表SCI文章8篇，参编著作多部。
1. Yaping Guan; Encheng Zhang; Cheng Zhang; Zhihan Ye; Feng Zhu ; Bile acid profiles in choledocholithiasis and their ability to predict common bile duct stone recurrence after endoscopic retrograde cholangiopancreatography treatment, Journal of Hepato-Biliary-Pancreatic Sciences, 2022, 00(00): 1-12
2.Yaping Guan, Fei Xu, Xiaodong Zhang, Xiao Fu, Jing Wang, Sentao Song, Yan Sun, Qiongying Yuan, Feng Zhu. Roles of ursodeoxycholic acid in the bile biochemistry and metabolomics in patientswith choledocholithiasis: a prospective study. Metabolomics. 2022 Jul 1;18(7):46（通讯作者）
3.Feng Zhu, Yaping Guan, Jing Wang. Efficacy and safety of the rotatable sphincterotome during ERCP in patients with prior Billroth II gastrectomy (with videos). Surg Endosc. 2021 Aug; 35(8):4849-4856.
4.F Zhu , Y Guan , R Zhang.Inhibition of JAK2 Signaling Alleviates Hyperlipidemia-Intensified Caerulin-Induced Acute Pancreatitis In Vivo. Curr Mol Med. 2017; 17(5):381-387.
5.Yaping Guan, Feng Zhu. Circulating levels of molecules associated with JAK2/STAT3 signaling pathway in patients with acute pancreatitis. Int J Clin Exp Pathol 2017;10(2):1984-1990.（通讯作者）
6.F Zhu , Y Guan , R Zhang. High-Dose Linoleic Acid Activated JAK2-STAT3 Signaling Pathway Involved in Cytokine Production and Lipogenesis in Pancreatic Exocrine Cells. Curr Mol Med. 2016;16(7):668-676.
7.Lv S, Gao J, Zhu F, Li Z, Gong Y, Xu G, Ma L Transthyretin, identified by proteomics, is overabundant in pancreatic juice from pancreatic carcinoma and originates from pancreatic islets. Diagn cytopathol. 2011, 39(12):875-881.（共同第一作者）
8.Gao J, Zhu F, Lv S, Li Z, Ling Z, Gong Y, Jie C, Ma L.Identification of pancreatic juice proteins as biomarkers of pancreatic cancer. oncol rep, 2010,23(6):1683-1692.（共同第一作者）
Presided over and participated in 3 projects of the National Natural Science Foundation of China.
To preside over a project supported by the National Natural Science Foundation of China:
Effect of free fatty acids on JAK2/STAT3 pathway in hypertriglyceridemia-associated acute pancreatitis. Project approval number: 81270546.
Participate in 2 National Natural Science Foundation projects:
The mechanism of intestinal motility disturbance caused by cholestasis through bile acid receptor GpBAR1 pathway.
Approval number: 81100257.
Study on the mechanism of apoptosis of colon cancer cells induced by LKB1/AMPK regulating aerobic glycolysis signal pathway. Approval number: 81272745.
Published 8 SCI articles as the first author or corresponding authorand participated in editing many books.
1. Yaping Guan; Encheng Zhang; Cheng Zhang; Zhihan Ye; Feng Zhu ; Bile acid profiles in choledocholithiasis and their ability to predict common bile duct stone recurrence after endoscopic retrograde cholangiopancreatography treatment, Journal of Hepato-Biliary-Pancreatic Sciences, 2022, 00(00): 1-12
2.Yaping Guan, Fei Xu, Xiaodong Zhang, Xiao Fu, Jing Wang, Sentao Song, Yan Sun, Qiongying Yuan, Feng Zhu. Roles of ursodeoxycholic acid in the bile biochemistry and metabolomics in patientswith choledocholithiasis: a prospective study. Metabolomics. 2022 Jul 1;18(7):46（corresponding author）
3.Feng Zhu, Yaping Guan, Jing Wang. Efficacy and safety of the rotatable sphincterotome during ERCP in patients with prior Billroth II gastrectomy (with videos). Surg Endosc. 2021 Aug; 35(8):4849-4856.
4.F Zhu , Y Guan , R Zhang.Inhibition of JAK2 Signaling Alleviates Hyperlipidemia-Intensified Caerulin-Induced Acute Pancreatitis In Vivo. Curr Mol Med. 2017; 17(5):381-387.
5.Yaping Guan, Feng Zhu. Circulating levels of molecules associated with JAK2/STAT3 signaling pathway in patients with acute pancreatitis. Int J Clin Exp Pathol 2017;10(2):1984-1990.（corresponding author）
6.F Zhu , Y Guan , R Zhang. High-Dose Linoleic Acid Activated JAK2-STAT3 Signaling Pathway Involved in Cytokine Production and Lipogenesis in Pancreatic Exocrine Cells. Curr Mol Med. 2016;16(7):668-676.
7.Lv S, Gao J, Zhu F, Li Z, Gong Y, Xu G, Ma L Transthyretin, identified by proteomics, is overabundant in pancreatic juice from pancreatic carcinoma and originates from pancreatic islets. Diagn cytopathol. 2011, 39(12):875-881.（co-first author）
8.Gao J, Zhu F, Lv S, Li Z, Ling Z, Gong Y, Jie C, Ma L.Identification of pancreatic juice proteins as biomarkers of pancreatic cancer. oncol rep, 2010,23(6):1683-1692.（co-first author）
