1. 临床研究：

(1) 小肠克罗恩病(合并狭窄)的临床及营养治疗研究

(2) 基于生物标志物或小肠影像学的药物疗效预测与手术风险预测研究

(3) 肛周瘘管型克罗恩病的临床研究

(4) 中医药在IBD中的疗效与机制研究

2. 基础研究：

(1) 克罗恩病肠系膜脂肪疾病发病机制中的研究；

(2) 淋巴管内皮及淋巴管功能在克罗恩病发病机制中的作用

(3) 脂肪干细胞和肠道微生物及其外泌体在IBD发病机制中的作用

1. Clinical research:

(1) The study on the optimized and nutrition treatment for stricture Cronh’s disease with small bowel involvement

(2) The predictive study on efficacy or surgery based on biomarkers and small bowel cross section examination

(3) The clinical study on perianal Crohn’s disease

(4) Study on the therapeutic effect and mechanism of traditional Chinese medicine in IBD

2. Basic research

(1) The role of creeping fat in the pathogenesis of Crohn’s disease

(2) The role of lymphatic endothelial cells and lymphatic function in the pathogenesis of Crohn

消化内科主任医师；，副教授

1.中华医学会上海消化系疾病分会小肠学组成员

2.上海医师协会肛肠分会第一届委员会委员

3.中华医学会上海消化系疾病分会第十届委员会炎症性肠病学组

4.中国医师协会肛肠分会炎症性肠病专业委员会成员

5.中国医学装备协会消化病分会第一届委员会炎症性肠病学组委员

6. 《中华炎性肠病杂志》特约审稿专家

Department of Gastroenterologu; Chief Attending; Associated professor

1. Member of the Small Intestinal Group of the Shanghai Digestive Disease Branch of the Chinese Medical Association

2. Member of the First Committee of the Anorectal Branch of the Shanghai Medical Association

3. Member of the Inflammatory Bowel Disease Group of the 10th Committee of the Shanghai Digestive Disease Branch of the Chinese Medical Association

4. Member of the Inflammatory Bowel Disease Professional Committee of the Anorectal Branch of the Chinese Medical Doctor Association

5. Member of the Inflammatory Bowel Disease Group of the First Committee of the Digestive Disease Branch of the Chinese Medical Equipment Association

6.Reviewer for the Chinese Journal of Inflammatory Bowel Disease

1.主持炎症性肠病领域的国家自然科学基金3项；

2.牵头全国多中心临床研究 1项(临床研究注册号：ChiCTR230075237)

1.Hosted three National Natural Science Foundation projects in the field of inflammatory bowel disease

2. Lead a national multicenter clinical research project (Clinical study registration number: ChiCTR230075237)

3. 近年发表论文(Recent publications)：

Shu W, Wang Y, Li C, Zhang L, Zhuoma D, Yang P, Yan G, Chen C, Ba Y, Du P, Wang X. Single-cell expression atlas reveals cell heterogeneity in creeping fat of Crohn’s disease. Inflamm Bowel Dis. 2023 Jan 28:izac266.

德吉卓玛, 杨鹏宇，张蕾，李传顶，吴亚玲，王晓蕾. 转换环孢素与英夫利西单抗治疗难治性溃疡性结肠炎的短期疗效与临床结局比较.5848vip威尼斯电子游戏学报(医学版).2022,43(6):799-804

杨鹏宇,李传顶,德吉卓玛,刘占举,曾美英,王晓蕾*. 基于临床-影像学特征构建模型预测抗肿瘤坏死因子⁃α单克隆抗体维持治疗小肠克罗恩病的疗效.中华炎性肠病杂志. 2022,6(4):304-311.

Lei Zhang, Chen Ye2, Peng Li , Chuanding Li , Weigang Shu , Yujie Zhao and Xiaolei Wang. ADSCs stimulated by VEGF-C alleviate intestinal inflammation via dual mechanisms of enhancing lymphatic drainage by a VEGF-C/ VEGFR-3-dependent mechanism and inhibiting the NF-κB pathway by the secretome. Stem Cell Research & Therapy, (2022) 13:448. IF 8.079

Yaling Wu, Zijie Wang, Mengmeng Xing, Bingyan Li, Zhiyuan Liu, Peng Du, Huinan Yang, Xiaolei Wang. The Specific Changes of Urine Raman Spectra Can Serve as Novel Diagnostic Tools for Disease Characteristics in Patients with Crohn