1、炎症性肠病的病理生理机制研究(The pathogenesis of inflammatory bowel disease)；
2、炎症性肠病临床诊治优化模式探索（to explore optimizing clinical management for inflamamotory bowel disease）；
3、肠道菌群及代谢产物的研究（intestinal flora and metabolites）

/

1）附课题/项目/人才计划：（1）国家自然科学基金青年项目, 81800487, TOB1对炎症性肠病肠黏膜组织内Th1/Th17细胞激活的免疫调节机制研究,2019/01-2021/12,21万,在研,主持

（2）5848vip威尼斯电子游戏青年人才培育类青优项目, 22120180574, TOB1对炎症性肠病肠黏膜组织内Th1/Th17细胞激活的免疫调节机制研究,2019/01-2020/12,5万,在研,主持

（3）5848vip威尼斯电子游戏附属第十人民医院攀登人才计划，优秀青年医师A类，炎症性肠病合并心肌缺血发生风险的相关研究，2018/09-2020/08，8万元，结题，主持

（4）5848vip威尼斯电子游戏基础研究能力提升计划项目，22120170034，Th22 细胞在炎症性肠病发生发展中的免疫调节机制研究,2017/10-2018/06,5万元，结题，主持

（5）国家自然科学基金重点项目,81630017,CD177+中性粒细胞在炎症性肠病发生发展过程中的免疫调节机制,2017/01-2021/12,278万,在研,参加

2）附发表论文：(1) Leilei Fang(#) , Zhi Pang (#), Weigang Shu, Wei Wu, Mingming Sun, Yingzi Cong, Zhanju Liu(*) , Anti-TNF Therapy Induces CD4+ T-Cell Production of IL-22 and Promotes Epithelial Repairs in Patients With Crohn Crohn's Disease[J].Inflammatory bowel diseases.2018,24(8):1733-44.

(2) Zhou G(#); Yu L(#); Fang L; Yang W; Yu T; Miao Y; Chen M; Wu K; Chen F; Cong Y; Liu Z, CD177(+) neutrophils as functionally activated neutrophils negatively regulate IBD[J].Gut.2018,67(6):1052-63.

(3) He,Chong(#), Yu,Tianming(#) , Shi,Yan, Ma,Caiyun, Yang,Wenjing, Fang,Leilei, Sun,Mingming, Wu,Wei, Xiao,Fei, Guo,Feifan, Chen,Minhu, Yang,Hong, Qian, Jiaming, Cong,Yingzi(*), Liu,Zhanju(*), MicroRNA 301A Promotes Intestinal Inflammation and Colitis-Associated Cancer Development by Inhibiting BTG1.,Gastroenterology,2017.02.10

(4) He, Chong(#) , Shi, Yan(#) , Wu, Ruijin(#) , Sun, Mingming, Fang, Leilei, Wu, Wei, Liu, Changqin, Tang, Maochun, Li, Zhong, Wang, Ping, Cong,Yingzi, Liu,Zhanju(*) , miR-301a promotes intestinal mucosal inflammation through induction of IL-17A and TNF-alpha in IBD.,Gut,2016.12.01,65(12):1938~1950

(5) Zhou,Guangxi, Yu,Lin, Yang,Wenjing, Wu,Wei, Fang,Leilei, Liu,Zhanju(*) , Blockade of PLD2 Ameliorates Intestinal Mucosal Inflammation of Inflammatory Bowel Disease.,Mediators Inflamm,2016.01.01,2016:2543070~2543070