癌症表观遗传学和肿瘤靶向药物耐药 Cancer epigenetics and drug resistance of targeted therapy；肿瘤免疫 tumor immunity

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课题和基金项目 Projects and Grants：1.5848vip威尼斯电子游戏青年优秀人才计划项目，肺腺癌中EGFR基因靶向药物吉非替尼耐药基因的筛选和作用机制研究，项目批准号kx0151120171864，2017.01-2018.12 ，5万，主持；

2. 5848vip威尼斯电子游戏国自然培育计划，基于CRISPR-Cas9技术对肺腺癌中EGFR基因靶向药物奥西替尼耐药基因的筛选及作用机制研究, 项目批准号22120170107，2017.09-2018.12，5万，主持；

3. 国家自然基金青年项目，YAP1和NEK2在第三代EGFR-TKI耐药中的功能和机制研究，项目批准号31801111，201901-202112，27万，主持；

4. 上海市肺科医院梦想导师优秀青年人才计划，基于MeRIP-seq技术对肺癌表观转录组谱分析，项目批准号fkyq1910，201907-202206, 20万，主持；

5. 5848vip威尼斯电子游戏国自然培育计划，转录因子KLF4通过调控KRT19表达影响非小细胞肺癌细胞周期的作用和机制研究, 2019.09-2020.12，3万，主持

发表文章 Publications：1. Yin Liu, Ke Zhou, Xin-Yun Li, Shu-Hong Zhao and Jian-Hua Cao. Expression Profiling of Myoz1 Gene in Porcine Tissue and C2C12 Cells. Journal of Animal and Veterinary Advances 10(15): 1917-1921,2011；

2.H.H He, C.A. Meyer, S.S. Hu, M-W Chen, C. Zang, Yin Liu, P.K. Rao, T. Fei, H. Xu, H. Long, X.S. Liu M. Brown. Refined DNase-seq protocol and data analysis reveals intrinsic bias in transcription factor footprint identification. Nature methods (IF: 23.565) 11(10), 73-80, 2013；

3.Wang H, Zheng X, Fei T, Wang J, Li X, Liu Y, Zhang F. Towards pathway-centric cancer therapies via pharmacogenomic profiling analysis of ERK signalling pathway. Clin Transl Med, 2015, 4: 66；

4.Yin Liu, Teng Fei, Xiaoqi Zheng, Myles Brown, Peng Zhang, X.Shirley Liu, Haiyun Wang. An Integrative Pharmacogenomic Approach Identifies Two-drug Combination Therapies for Personalized Cancer Medicine. Sci. Rep. 6, 22120; doi: 10.1038/srep22120 (2016). (IF: 5.9)；

5.Liu Y, Chen S, Wang S, Soares F, Fischer M, Meng F, Du Z, Lin C, Meyer C, DeCaprio JA, Brown M, Liu XS, He HH. Transcriptional landscape of the human cell cycle. Proc Natl Acad Sci U S A, 2017, 114: 3473-3478. (IF: 9.661)；

6.Zheng R, Li Z, He F, Liu H, Chen J, Chen J, Xie X, Zhou J, Chen H, Wu X, Wu J, Chen B, Liu Y, Cui H, Fan L, Sha W, Liu Y, Wang J, Huang X, Zhang L, Xu F, Wang J, Feng Y, Qin L, Yang H, Liu Z, Cui Z, Liu F, Chen X, Gao S, Sun S, Shi Y, Ge B. Genome-wide association study identifies two risk loci for tuberculosis in Han Chinese. Nat Commun 2018;9(1):4072. (IF: 12.353)；

7.Wu X, Yang J, Tan G, Liu H, Liu Y, Guo Y, Gao R, Wan B, Yu F. Drug Resistance Characteristics of Mycobacterium tuberculosis Isolates From Patients With Tuberculosis to 12 Antituberculous Drugs in China. Front Cell Infect Microbiol 2019;9:345. (IF: 3.518)；

8.Li, Z., B. Wang, S. Gu, P. Jiang, A. Sahu, C. H. Chen, T. Han, S. Shi, X. Wang, N. Traugh, H. Liu, Y. Liu, Q. Wu, M. Brown, T. Xiao, G. M. Boland and X. Shirley Liu (2020). "CRISPR Screens Identify Essential Cell Growth Mediators in BRAF Inhibitor-resistant Melanoma." Genomics Proteomics Bioinformatics 18(1): 26-40. (IF: 6.597)；

9.Xingwei Cao, Qing Zhan, Yinjuan Guo, Jinghui Yang, Yin Liu, Baoshan Wan, Xiaocui Wu, Qiaoshi Zhong, Yaping Hang, Yanhui Chen, Yanping Xiao, Fangyou Yu, Longhua Hu. Genotypic Characterization of katG, inhA, and ahpC in Isoniazid-Resistant Mycobacterium tuberculosis Clinical Isolates in Shanghai, China. Jundishapur Journal of Microbiology. Ahvaz Vol. 12, Iss. 11, (Nov 2019): 1-6. DOI:10.5812/jjm.95713；

10.Min-yin Xu, Yin Liu, Li-rong Liu, Hong-xiu Wang, Jing-hui Yang, Wei-ping Wang, Zhong-ping Lang. Diagnostic value of interferon gamma release assays combined with IL-6 detection in active pulmonary tuberculosis. China Journal of Modern Medicine. 1005-8982 (2020) 10-0018-04；

11.Guo Y, Cao X, Yu J, Zhan Q, Yang J, Wu X, Wan B, Liu Y, Yu F. Antimicrobial Susceptibility of Mycobacterium abscessus Complex Clinical Isolates from a Chinese Tertiary Hospital. Infect Drug Resist 2020;13:2001-2010. (IF: 2.984)；

12.Yinjuan Guo; Xingwei Cao; Jinghui Yang; Xiaocui Wu; Yin Liu; Baoshan Wan; Longhua Hu; Hongxiu Wang; Fangyou Yu. Rifampin resistance-associated mutations in the RIF resistance-determining region (RRDR) of the rpoB gene of Mycobacterium tuberculosis clinical isolates in Shanghai, China；

13.Sujun Chen, Guanghui Zhu, Yue Yang, Fubo Wang, Yutian Xiao, Na Zhang, Xiaojie Bian, Yasheng Zhu, Yongwei Yu, Fei Liu, Keqin Dong, Javier Mariscal, Yin Liu, Fraser Soares, Helen Loo Yau, Bo Zhang, Weidong Chen, Chao Wang, Dai Chen, Qinghua Guo, Zhengfang Yi, Mingyao Liu, Michael Fraser, Daniel D De Carvalho, Paul C. Boutros, Dolores Di Vizio, Theodorus van der Kwast, Zhou Jiang, Song Wu, Jianhua Wang, Yinghao Sun, Housheng Hansen He, Shancheng Ren. Single cell analysis reveals onset of multiple progression associated transcriptomic remodellings in prostate cancer. Nature Cell Biology(IF: 20.042).(Accepted)