胃肠道肿瘤的临床根治手术和综合治疗 肥胖症的外科治疗和机理研究 Radical operation and comprehensive treatment of gastrointestinal tumors； Surgical treatment and mechanism of obesity
上海市第十人民医院大外科教学副主任 Deputy Director of Surgery Teaching, Shanghai Tenth People’s Hospital 中国医师协会外科学分会肥胖和糖尿病外科医师委员会委员Member of obesity and Diabetes Surgeons Committee, Surgery Branch, Chinese Medical Doctor Association 中国医师协会结直肠专委会腹腔镜专业委员会委员Member of Laparoscopic Group of Colorectal Professional Committee, Chinese Medical Doctor Association 中国研究型医院学会糖尿病与肥胖外科专业委员会委员Member of the Professional Committee of Diabetes and Bariatric Surgery, Chinese Association of Research Hospitals 国际肥胖和代谢外科减重联盟（IFSO）会员Member of The International Federation for the Surgery of Obesity and Metabolic Disorders 中国医药教育协会盆腔肿瘤专业委员会委员Member of pelvic Tumor Professional Committee, Chinese Medical Education Association 中国抗癌协会肿瘤营养专业委员会委员Member of Cancer Nutrition Committee, Chinese Anti-cancer Association 上海市普外科临床质量控制中心专家Expert of General Surgery Clinical Quality Control Center of Shanghai 上海市医学会普外分会胃肠外科学组委员Member of Gastrointestinal Surgery Group, General Branch of Shanghai Medical Association 上海医学会减重与代谢手术学组委员Member of Bariatric & Metabolic Surgery Group, Shanghai Medical Association
课题 Research Program
1. The modeling of colorectal cancer drug screening based on Patient derived organoid technique基于患者来源类器官技术替代试验动物的结直肠肿瘤用药检测模型构建；上海市科委21140902100（2021-2024）
2. Biological effects and internal mechanisms of gastric bypass surgery on glucose metabolism axis in rats胃旁路手术对大鼠葡萄糖代谢轴产生的生物学效应及内在机制研究；上海市卫健委20124293
3. Standardized perioperative management of laparoscopic "fast channel" surgery for elderly colorectal cancer老年结直肠癌腹腔镜下“快通道”手术围手术期处理规范化研究；卫生局重点20124017 论文Research Articles
1、Zhang Y,Zhu C,Wen X,Wang X, Li L,Rampersad S,Lu L,Zhou D,Qian C,Cui R, Zhang M,Yang P,Qu S,Bu L.Laparoscopic sleeve gastrectomy improves body composition and alleviates insulin resistance in obesity related acanthosis nigricans.Lipids Health Dis. 2017 Nov 7;16(1):209. 腹腔镜袖状胃切除术改善肥胖相关黑棘皮病患者的体成分和减轻胰岛素抵抗
2. Huang DD1, Ji YB2, Zhou DL2, Li B3, Wang SL4, Chen XL4, Yu Z5, Zhuang CL. Effect of surgery-induced acute muscle wasting on postoperative outcomes and quality of life. J Surg Res. 2017 Oct;218:58-66. doi: 10.1016/j.jss.2017.05.045. Epub 2017 Jun 10. 手术诱发急性肌肉萎缩对术后预后和生活质量的影响。
3. Yang TS, Yang XH, Chen X, Wang XD, Hua J, Zhou DL, Zhou B, Song ZS. MicroRNA-106b in cancer-associated fibroblasts from gastric cancer promotes cell migration and invasion by targeting PTEN. FEBS Lett. 2014 Jun 13;588(13):2162-9. doi: 10.1016/j.febslet.2014.04.050. Epub 2014 May 17胃癌肿瘤相关成纤维细胞中的MicroRNA-106b通过靶向PTEN促进细胞迁移和侵袭。
4、Wang SL1, Ma LL1, Chen XY1, Zhou DL2, Li B3, Huang DD2, Yu Z2, Shen X4, Zhuang CL. Impact of visceral fat on surgical complications and long-term survival of patients with gastric cancer after radical gastrectomy. Eur J Clin Nutr. 2017 Nov 29. 内脏脂肪对胃癌根治术后并发症及远期生存的影响。
5、Xue Fu, Lina Jin, Luyu Han, Yini Yuan,Qian Mu ,Hui Wang,Jian Yang, Guang Ning,Donglei Zhou,and Zhiguo Zhang.miR-129-5p Inhibits Adipogenesis through Autophagy and May Be a Potential Biomarker for Obesity. International Journal of Endocrinology.Volume 2019 miR-129-5p通过自噬抑制脂肪生成，可能是肥胖的潜在生物标志物
6、Zheng L, Zhou D, Lu L, Liu Z, Fang L. Effects of CO2 pneumoperitoneum on proliferation, apoptosis, and migration of gastrointestinal stromal tumor cells. Surgical Endoscopy volume 33, pages3384–3395(2019) 02 January 2019 CO2气腹对胃肠道间质瘤细胞增殖、凋亡和迁移的影响。
