1）骨关节病及运动医学的临床诊疗和技术创新，2）骨关节炎的多器官对话的机制探究， 3）糖尿病骨质疏松等骨代谢疾病的早期预防、发病机制及治疗；4）肩袖损伤为代表的腱骨愈合相关病理机制、临床治疗及可修复材料研发；

1) Clinical diagnosis, treatment and technological innovation of osteoarthritis and sports medicine, 2) Mechanism investigation of multi-organ dialog of osteoarthritis, 3) Early prevention, pathogenesis and treatment of diabetic osteoporosis and other bone metabolism diseases, 4) Pathological mechanism, clinical treatment and research and development of repairable materials related to tendon and bone healing represented by rotator cuff injury;

北美关节镜协会（AANA）会员、国际矫形与创伤外科学会（SICOT）中国学会上海分会委员、上海市医学会骨科学会关节镜学组委员、上海市医学会骨科学会关节学组青年委员、上海市医学会骨科分会“浦菁荟”关节学组委员、上海市医学会运动医学委员会委员、上海市创伤学会关节镜学组委员、上海市医师协会骨科医师分会运动医学工作组委员、上海市医学会骨质疏松委员会青年委员、上海市中西医结合学会骨伤科专业委员会青年委员。

A member of the Arthroscopy Association of North America (AANA), a member of the International Society for Orthopaedic and Trauma Surgery (SICOT) China Shanghai Chapter, a member of Shanghai Orthopaedic Association Arthroscopy Group, a member of Shanghai Orthopaedic Association Joint Group, a member of Shanghai Orthopaedic Association Joint Group, a member of Shanghai Orthopaedic Association Joint Group, a member of Shanghai Sports Medicine Committee, a member of Shanghai Traumatology Committee, a member of Shanghai Orthopaedic Physicians Branch, a member of Shanghai Orthopedics Working Group, a member of Shanghai Orthopedic Association Young Committee of Shanghai Society for Medical Science and Youth, and a member of Shanghai Orthopedic and Traumatology Committee of Shanghai Integrated Chinese and Western Medicine Society.

作为十院‘运动医学科’负责人，积极开展科研工作，在研究过程中具备主持攻关重大课题的能力，创新精神和创新能力较强，能把握本专业和本学科的研究热点和方向，并把科研和推广应用紧密结合，实现科研、教学和临床想互动，多次至法国安纳西运动医学中心、美国匹兹堡医疗中心、韩国MADI肩关节中心、美国亚利桑那州关节外科中心、美国南加洲骨科研究所、美国Hedley 骨科研究所等多家全球著名运动医学及关节中心深造，师从于Dr.Burkhart、Dr.Freddie Fu、Dr.Laffosse、Dr.Snyder、Dr.James Chow、吴海山教授等国际顶尖运动医学和关节外科教授。发明了肩关节镜下双排锚钉固定治疗上盂唇复合体/二头腱损伤、改良镜下二头腱转位治疗巨大肩袖损伤、改良镜下肱骨大结节骨折荷包式固定等多项新技术。于国内率先开展并推广了Superpath微创髋关节置换等新技术，推动了微创关节置换技术和理念在国内的发展。

迄今为止，近五年内以第一作者或通讯作者在《Aging cell》《Front Endocrinol》等国际著名期刊中发表SCI 论文9 篇，其中大于10 分的SCI 论文1 篇，大于5 分的SCI 论文5 篇（2021年影响因子），参与完成其他学术论文若干。主要主持国家自然基金（基于国人解剖特征的TKA 术中胫骨的假体旋转放置及相关生物力学研究，81000808，已结题）和上海市自然科学基金（SGLT1抑制剂Mizagliflozin介导GSH-Nrf2信号通路对糖尿病性骨质疏松的影响及机制研究，23ZR1449200，在研）及上海市崇明区可持续发展科技创新行动计划（肠道菌群在骨关节炎和骨质疏松中的作用及机制研究，CKY2022-38），安徽省教育厅高等学校科研项目重大专项等多项市局及以上课题，发表专利5项。

As the person in charge of the 'Sports Medicine Section' of the Shanghai 10th Hospital, I actively carries out scientific research, has the ability to preside over the attack of major topics in the research process, has a strong spirit of creativity and innovation, is able to grasp the hotspot and direction of the research of this specialty and this discipline, and closely combines scientific research and promotion of its application, realizing the interaction of scientific research, teaching and clinical want, and has been to Annecy Sports Medicine Center in France, Pittsburgh Medical Center in the United States, MADI Shoulder Center in Korea, Arizona Joint Surgery Center in the United States, Southern California Orthopaedic Institute in the United States, Hedley Orthopaedic Institute in the United States and other famous sports medicine and joint centers in the world for further study, and has been trained under the supervision of Dr. Burkhart, Dr. Freddie Fu, Dr. Laffosse, Dr. Snyder, Dr. Snyder, Dr. Snyder, Dr. Laffosse, and Dr. Laffosse. Dr. Burkhart, Dr. Freddie Fu, Dr. Laffosse, Dr. Snyder, Dr. James Chow, Prof. Wu Haisan and other top international sports medicine and joint surgery professors. I also invented a number of new techniques, such as arthroscopic double-row anchor fixation for shoulder arthroscopy to treat superior glenoid labrum complex/biceps tendon injuries, modified arthroscopic biceps tendon transposition to treat giant rotator cuff injuries, and modified arthroscopic purse-string fixation for greater tuberosity fracture of humerus, etc. I was the first to develop and popularize the Surgical System for the shoulder in China. I was the first in China to develop and popularize new techniques such as Superpath minimally invasive hip replacement, which promoted the development of minimally invasive joint replacement techniques and concepts in China.

So far, in the past five years, I have published 9 SCI papers as the first author or corresponding author in international journals such as Aging cell, Front Endocrinol, etc., including 1 SCI paper with a score of more than 10, 5 SCI papers with a score of more than 5 (impact factor in 2021), and participated in the completion of a number of other academic papers. I have been the main sponsor of the National Natural Science Foundation of China (Study on the rotational placement of prosthesis and related biomechanics of the tibia in TKA based on the anatomical characteristics of Chinese people, 81000808, completed) and the Shanghai Natural Science Foundation of China (Study on the effect of GSH-Nrf2 signaling pathway mediated by Mizagliflozin, an inhibitor of SGLT1, on diabetic osteoporosis and the mechanism of diabetic osteoporosis, 23ZR1449200, completed). 23ZR1449200, under research) and the Science and Technology Innovation Action Plan for Sustainable Development of Chongming District, Shanghai (Research on the role and mechanism of intestinal flora in osteoarthritis and osteoporosis, CKY2022-38), a number of municipal bureaus and above, such as a major specialization of the research projects of higher education institutions of the Department of Education of Anhui Province, and the publication of five patents.

The list of SCI paper:

Z. Guan*, L. Luo, S. Liu, Z. Guan, Q. , Tao K*, The gut microbiota metabolite capsiate regulate SLC2A1 expression by targeting HIF-1α to inhibit Knee Osteoarthritis-induced ferroptosis, Aging cell. (2023). DOI: 10.1111/ACEL.13807. (Q1, IF=11.01)

Song Y#, Wu Z, Wang M, Liu S, Cong R, Tao K*. Arthroscopic Modified Double-Row Biceps Tenodesis versus Labral Repair for the Treatment of Isolated Type II SLAP Lesions in Non-Overhead Athletes. Orthop Surg. 2022 Jul;14(7):1340-1349. doi: 10.1111/os.13229. Epub 2022 May 27. PMID: 35633041; PMCID: PMC9251294.（IF: 2.279）

Guan Z, Liu S, Luo L, Wu Z, Lu S*, Guan Z*, Tao K*. Identification of Ferroptosis-Related Genes as Biomarkers for Sarcoma. Front Cell Dev Biol. 2022 Mar 1;10:847513. doi: 10.3389/fcell.2022.847513. PMID: 35309947; PMCID: PMC8929291. （IF: 6.081）

Guan Z, Luo L, Liu S, Guan Z*, Zhang Q*, Li X*, Tao K*. The Role of Depletion of Gut Microbiota in Osteoporosis and Osteoarthritis: A Narrative Review. Front Endocrinol (Lausanne). 2022 Mar 28;13:847401. doi: 10.3389/fendo.2022.847401. PMID: 35418947; PMCID: PMC8996773. （IF: 6.055）

Zhou Q, Guan Z, Liu S, Xuan Y, Han G, Chen H, Jin X*, Tao K*, Guan Z*. The effects of metformin and alendronate in attenuating bone loss and improving glucose metabolism in diabetes mellitus mice. Aging (Albany NY). 2022 Jan 14;14(1):272-285. doi: 10.18632/aging.203729. Epub 2022 Jan 14. PMID: 35027504; PMCID: PMC8791222. （IF: 5.955）

Song Y, Liu SF, Wu Z, Wang M, Cong RJ*, Tao K*. Effects of preoperative serum vitamin D levels on early clinical function outcomes and the moderate-to-severe pain prevalence in postmenopausal women after primary total knee arthroplasty. Menopause. 2021 May 3;28(8):893-898. doi: 10.1097/GME.0000000000001789. PMID: 33950032. （IF: 3.310）

Wang W, Chen Q, Wang J, Li T, Song G, Tao K*, Liu J*, Wu Z*. The level of thymic stromal lymphopoietin and its gene polymorphism are associated with rheumatoid arthritis. Immunobiology. 2021 Mar;226(2):152055. doi: 10.1016/j.imbio.2021.152055. Epub 2021 Jan 23. PMID: 33535091. （IF: 3.152）

Li R, Cai M*, Tao K*. Arthroscopic reduction and fixation for displaced greater tuberosity fractures using the modified suture-bridge technique. Int Orthop. 2017 Jun;41(6):1257-1263. doi: 10.1007/s00264-017-3461-y. Epub 2017 Apr 11. PMID: 28401278. （IF: 3.479）

Guan Z, Luo L, Liu S, Guan Z*, Zhang Q*, Wu Z* and Tao K* (2022) The role of TGR5 as an onco-immunological biomarker in tumor staging and prognosis by encompassing the tumor microenvironment. Front. Oncol. 12:953091. （IF: 6.25）