泌尿系肿瘤的病因研究及微创治疗，尤其是肾脏肿瘤的病因研究和临床治疗学研究 (Etiological research and minimally invasive treatment of urinary tract tumors, especially the etiological research and clinical therapeutic research of renal tumors);

泌尿外科结石的腔镜诊疗及机制研究，尤其是对复杂肾结石的诊断、治疗以及病因学研究 (Endoscopic diagnosis and treatment and mechanism research of urolithiasis, especially the diagnosis, treatment and etiology of complex kidney stones);

男性生殖的病因研究和临床治疗学研究 (Etiological research and clinical therapeutic research of male Reproductive Medicine)。

现任5848vip威尼斯电子游戏附属第十人民医院泌尿外科行政副主任，结石中心主任 (Deputy director of Urology, Department of Shanghai Tenth People’s Hospital, Tongji University School of Medicine)

中华医学会泌尿外科学分会感染与炎症学组委员 (Member of Infection and Inflammation Group of Urology branch of Chinese Medical Association)

上海市医学会泌尿外科分会委员 (Member of Urology branch of Shanghai Medical Association)

上海医学会泌尿外科分会结石学组委员 (Member of Urolithiasis group of Urology branch of Shanghai Medical Association)

上海中西医结合学会性医学专委会委员 (Member of Sexual Medicine Group of Shanghai Association of Chinese Integrative Medicine)

国家自然科学基金评审专家 (Evaluation Expert of National Natural Science Foundation of China)

上海市泌尿外科会诊中心专家组专家 (Expert of Shanghai Urology Consultation Center)

5848vip威尼斯电子游戏青年科学家联谊会成员 (Member of Young Scientists Association of Tongji University)

《中华实验外科杂志》，《5848vip威尼斯电子游戏学报》，《中华临床医师杂志》等杂志审稿专家

教育部学位中心博士论文评审专家 (Reviewer of Chinese Journal of Experimental Surgery, Journal of Tongji University, Chinese Journal of Clinicians, etc)

主持和参加科研课题10余项。以第一负责人先后主持国家自然科学基金面上项目3项，上海市自然科学基金项目3项，上海申康医院发展中心基金项目1项，上海市卫生局青年基金1项，上海市卫健委课题1项，5848vip威尼斯电子游戏附属第十人民医院泌尿系结石特色专科基金1项，5848vip威尼斯电子游戏附属第十人民医院后备博士生导师基金1项，5848vip威尼斯电子游戏附属第十人民医院350项目1项，5848vip威尼斯电子游戏教材出版基金2项。主编专著3部，主译专著1部，参编专著2部，以第一作者和通讯作者发表SCI收录论文41篇，最高分值15分。中文核心期刊30余篇，2006年获得上海市第十人民医院最佳主治医师称号，2009年获得上海市第十人民医院临床成果二等奖，2012年获得首届患者心中好医生称号。先后获得国家专利6项,2011年获得中华医学科技奖三等奖，2012年获教育部科技进步一等奖及上海市医学科技奖二等奖。

Professor Xu presided and participated in more than 10 scientific research projects. As the first person in charge, he has successively presided over 3 general projects of the National Natural Science Foundation of China, 2 projects of the Shanghai Natural Science Foundation, 1 project of Shanghai Hospital Development Center,1 project from the Shanghai Municipal Health Bureau Youth Fund, 1 project of the Shanghai Municipal Health and Health Commission, and 2 textbook publishing funds of Tongji University. Professor Xu edited 2 monographs and translated 1 monograph. He also participated in editing 2 monographs and published 39 SCI-indexed papers as the first author and corresponding author, with a maximum score of 15 points. He has published more than 30 articles in Chinese core journals. In 2006, he was awarded the title of Best Attending Physician in Shanghai Tenth People’s Hospital. In 2009, he won the second prize for clinical achievements in Shanghai Tenth People’s Hospital. He has successively won 6 national patents, the third prize of the China Medical Science and Technology Award in 2011, the first prize of the Science and Technology Progress Award of the Ministry of Education, and the second prize of the Shanghai Medical Science and Technology Award in 2012.

主持国家自然科学基金项目 (The National Natural Science Foundation of China project presided by Professor Xu)：

1. REGγ通过调控IκBε对睾丸间质细胞炎症的作用及分子机制研究 (Effects of REGγ on Leydig cell inflammation by regulating IκBε and its molecular mechanism);

2. REG通过调控P53对雄性生殖发育中的作用及分子机制研究 (The role and molecular mechanism of REG in male reproductive development by regulating P53);

3. 条件增敏和敲除糖皮质激素受体活性导致Leydig细胞睾酮降低的机制 (Mechanism of testosterone reduction in Leydig cells by conditional sensitization and knockdown of glucocorticoid receptor activity)。

代表性论文 (Representative papers）：

Zhai W, Li S, Zhang J, Chen Y, Ma J, Kong W, Gong D, Zheng J, Xue W, Xu Y. Sunitinib suppressed miR-452-5p facilitates renal cancer cell invasion and metastasis through modulating SMAD4/SMAD7 signals. Mol Cancer. 2018 Nov 12;17(1):157. (通讯作者, IF: 15.302)

Liu H, Hu G, Wang Z, Liu Q, Zhang J, Chen Y, Huang Y, Xue W, Xu Y, Zhai W. circPTCH1 promotes invasion and metastasis in renal cell carcinoma via regulating miR-485-5p/MMP14 axis. Theranostics. 2020 Aug 29;10(23):10791-10807. (通讯作者, IF: 8.579)

Li S, Huang C, Hu G, Ma J, Chen Y, Zhang J, Huang Y, Zheng J, Xue W, Xu Y, Zhai W. Tumor-educated B cells promote renal cancer metastasis via inducing the IL1β/HIF-2α/Notch1 signals. Cell Death Dis. 2020 Mar 2;11(3):163. (通讯作者, IF: 6.304)

代表性专著 (Representative monograph)：

尿路结石诊疗精要 人民卫生出版社 北京 2022 主编

泌尿系统结石现代诊疗学 吉林出版集团 吉林 2015 主编

现代临床泌尿外科学 5848vip威尼斯电子游戏出版社 上海 2008 主编

现代泌尿生殖肿瘤外科学 5848vip威尼斯电子游戏出版社 上海 2004 主译