【主持的科研项目】:
(1) 国家自然科学基金面上项目,82171657,G蛋白偶联雌激素受体驱动cGAS-STING通路促进复发性自然流产发生的机制研究,2022/01-2025/12,54万元,在研,主持;
(2) 国家自然科学基金面上项目,81971384,蜕膜巨噬细胞中GPR133基因表达异常在复发性流产发生中的作用及机制研究,2020/01-2023/12,55万,在研,主持;
(3) 国家自然科学基金青年项目,81501270,赖氨酰氧化酶在子痫前期发生发展中的作用及其机制研究,2016/01-2018/12,18万,结题,主持;
(4) 上海市动物专项,22140903400,基于Gls1基因敲除的子宫内膜蜕膜化不良的动物模型构建,2022/03-2025/03,20万元,在研,主持
【代表性论文】:
(1) Xu XH#, Jia Y, Zhou X, Xie D, Huang X, Jia L, Zhou Q, Zheng Q, Zhou X, Wang K*, Jin LP*. Downregulation of lysyl oxidase and lysyl oxidase-like protein 2 suppressed the migration and invasion of trophoblasts by activating TGF-β/collagen pathway in preeclampsia. Exp Mol Med. 2019, 51 (2): 20;
(2) Hao F#, Tang LC#, Sun JX, Li WX, Zhao Y, Xu XH*, Jin LP*. Decreased nitric oxide content mediated by asymmetrical dimethylarginine and protein L-arginine methyltransferase 3 in macrophages induces trophoblast apoptosis: a potential cause of recurrent miscarriage. Hum Reprod. 2021, 36(12):3049-3061.
(3) Xu XH#, Bao Y#, Wang X, Yan F, Guo S, Ma Y, Xu D, Jin L, Xu J*, Wang J*. Hypoxic-stabilized EPAS1 proteins transactivate DNMT1 and cause promoter hypermethylation and transcription inhibition of EPAS1 in non-small cell lung cancer. FASEB J. 2018; 12, 32(12): 6694-6705.
(4) Yao Y#, Hao F, Tang LC, Xu XH*, Jin L*. Downregulation of HDAC8 expression decreases CD163 levels and promotes the apoptosis of macrophages by activating the ERK signaling pathway in recurrent spontaneous miscarriage. Mol Hum Reprod. 2020 Jul 1;26(7):521-531;
(5) Xu XH#, Tang LC#, Hao F, Jin LP*. Upregulation of miR-29a suppressed the migration and invasion of trophoblasts by directly targeting LOXL2 in preeclampsia. Journal of hypertension. J Hypertens. 2021, 39(8):1642-1651.
(6) Tang LC, Xu XH*, Jin LP*. Molecular characteristics and possible function of innate lymphoid cells under different tissue conditions. Cytokine Growth Factor Rev. 2020, 52:15-24.
(7) Xu XH#, Dong SS, Guo Y, Yang TL, Lei SF, Papasian CJ, Zhao M, Deng HW*. Molecular genetics studies of gene identification for osteoporosis: the 2009 update. Endocr Rev. 2010; 31(4):447-505.