妇科肿瘤与内镜技术Research Interests:1. The mechanism of invasion and metastasis in ovarian cancer；2. Clinical application of laparoscopic surgery in treatment of gynecological malignancies

上海市第一妇婴保健院妇科主任
中华医学会妇科肿瘤学分会委员
上海市医学会妇产科分会委员
中华医学会新疆生产建设兵团妇产科分会副主任委员
Senior Physician & Head, Department of Gynecological Oncology, Shanghai First Maternity and Infant Hospital.
Member of Gynecologic Oncology Branch of Chinese Medical Association.
Member of Obstetrics and Gynecology Branch of Shanghai Medical Association.
Deputy chairman of obstetrics and gynecology in Xinjiang Production and Construction Corps Branch of Chinese Medical Association.

开展多项妇科恶性肿瘤的基础与临床研究，在宫颈癌发生机制、早期筛查、早期治疗和卵巢癌侵袭、转移等领域的研究较为深入。先后主持国家自然科学基金面上项目1项，完成教育部留学回国人员科研启动基金1项，完成石河子大学高层次人才科研启动项目1项，石河子大学课题1项；同时主持国家科技惠民计划子课题1项，主持上海市卫计委重点项目1项；获新疆兵团科技进步二等奖（省级）2项，兵团科技进步三等奖2项；研究成果发表SCI收录论文8篇，单篇最高影响因子4.057，发表中文核心期刊10余篇。

Research Interests:

The mechanism of invasion and metastasis in ovarian cancer

Clinical application of laparoscopic surgery in treatment of gynecological malignancies

Research Foundation:

1."β-hCG-ERK1/2-MMP-2" signaling pathway in ovarian cancer invasion and metastasis, founded by National Natural Science Foundation.

2.“To investigate the clinical significance of KRT7 and MMP in the diagnosis and treatment of CIN”, founded by Shanghai Municipal Commission of Health and Family Planning.

3.Huimin sub-project: An appropriate technologies application in diagnosis and treatment of gynecologic diseases in border areas of Xinjiang Production and Construction Corps, founded by national science and technology.

4.Correlation of β-hCG expression with epithelial-mesenchymal transition in epithelial ovarian cancer tissue, founded by Ministry of education scientific research foundation。

5.High-level personnel project: The establishment of ovarian cancer tissue microarray and related research, founded by Shihezi University Scientific Research Program.

Research Award：1.Awarded twice for Second Prize of Science and Technology Progress of Xinjiang Production and Construction Corps (Provincial).

2.Awarded twice for Third Prize of Science and Technology Progress of Xinjiang Production and Construction Corps (Provincial).

Current Publications：1.Liu N, Peng SM, Zhan GX, Yu J, Wu WM, Gao H, Li XF, Guo XQ. Human chorionic gonadotropin β regulates epithelial-mesenchymal transition and metastasis in human ovarian cancer.Oncol Rep. 2017 Jul 14. doi: 10.3892/or.2017.5818.

2.Pan Z, Zheng W, Zhang J, Gao R, Li D, Guo X, Han H, Li F, Qu S, Shao R. Down-regulation of the expression of CCAAT/enhancer binding protein α gene in cervical squamous cell carcinoma. BMC Cancer 2014, 14:417

3.Schauer IG, Zhang J, Xing Z, Guo X, Mercado-Uribe I, Sood AK, Huang P, Liu J. Interleukin-1β promotes ovarian tumorigenesis through a p53/NF-κB-mediated inflammatory response in stromal fibroblasts. Neoplasia. 2013 Apr;15(4):409-20.

4.Guo X, Liu G, Schauer IG, Yang G, Mercado-Uribe I, Yang F, Zhang S, He Y, Liu J. Overexpression of the β subunit of human chorionic gonadotropin promotes the transformation of human ovarian epithelial cells and ovarian tumorigenesis. Am J Pathol. 2011 Sep;179(3):1385-93. Epub 2011 Jul 18.

5.Zhang J, Guo X, Chang DY, Rosen DG, Mercado-Uribe I, Liu J.CD133 expression associated with poor prognosis in ovarian cancer. Mod Pathol. 2012 Mar;25(3):456-64. doi: 10.1038/modpathol.2011.170. Epub 2011 Nov 11.

6.Yang F, Guo X, Yang G, Rosen DG, Liu J. AURKA and BRCA2 expression highly correlate with prognosis of endometrioid ovarian carcinoma. Mod Pathol. 2011 Mar 25.

7.Yang G, Rosen DG, Liu G, Yang F, Guo X, Xiao X, Xue F, Mercado-Uribe I, Huang J, Lin SH, Mills GB, Liu J. CXCR2 promotes ovarian cancer growth through dysregulated cell cycle, diminished apoptosis, and enhanced angiogenesis. Clin Cancer Res. 2010 Aug 1;16(15):3875-86.

8.Yang G, Chang B, Yang F, Guo X, Cai KQ, Xiao XS, Wang H, Sen S, Hung MC, Mills GB, Chang S, Multani AS, Mercado-Uribe I, Liu J. Aurora kinase A promotes ovarian tumorigenesis through dysregulation of the cell cycle and suppression of BRCA2. Clin Cancer Res. 2010 Jun 15;16(12):3171-81.

9.刘彦芳,郭晓青,高玉梅等.β-hCG、TGF-β和TβR-I在卵巢上皮性癌中的表达及意义[J].中国妇幼保健,2015,30(14):2257-2260.

10.高玉梅,郭晓青,刘彦芳等.N-cadherin在卵巢癌发生和进展中的作用及意义[J].中国妇幼保健,2015,30(13):2071-2073.

11.韩凌斐,郭晓青,胡家昌等.宫颈癌患者外周血髓源性抑制细胞的比例及其临床意义[J].华中科技大学学报（医学版）,2015,(1):32-36.

12.耿欣,刘彦芳,高玉梅,郭晓青.β-HCG、ERK1/2及 MMP -2在卵巢癌中的表达及意义[J].广东医学,2015,(9):1371-1374.

13.何波,郭晓青.E-cadherin在晚期卵巢癌原发灶和转移灶中的表达及意义[J].中国妇幼保健,2014,29(9):1420-1423.

14.李园园,王英红,郭晓青等.高危型HPV阳性宫颈病变患者治疗后随访的相关研究[J].中国妇幼保健,2013,28(14):2194-2198.

15.张静,郭晓青,Jing-songLIU等.卵巢浆液性癌的两级分级系统及其临床意义[J].中华妇产科杂志,2011,46(10):739-741.等