郭毅博士从事人类辅助生殖技术胚胎实验室的临床、科研及教学工作近14年。临床研究主要致力于辅助生殖过程中未成熟卵母细胞及胚胎培养的优化及精液生物标记物的筛选，基础研究聚焦于高龄及环境因素对配子及植入前胚胎表观修饰的影响，并探索这类因素对子代疾病发生的机制研究。目前以第一负责人主持2项国家自然科学基金项目，1项中华医学会临床研究项目。
主持项目
1.高龄雄性精子tsRNA通过调控早期胚胎基因表达介导子代焦虑样行为发生的机制研究. 国家自然科学基金 面上项目
2.高龄父亲精子miRNA表达谱异常及其在子代自闭症谱系障碍（ASD）发生中的作用和机制研究.国家自然科学基金 青年项目
3.比较纺锤体观察法与传统极体法对短时授精后部分受精失败患者的治疗结局:一项随机双盲对照研究. 中华医学会
近五年发表文章:
1. Jianing Niu# , Qiurong Chang#, Junting Xu#, Jinli Li, Wenqiang Liu, Zhiqin Chen, Xianting Jiao*, Yi Guo*, Xiaoming Teng* Relationship of the levels of reactive oxygen species in the fertilization medium with the outcome of in vitro fertilization following brief incubation. Frontiers in Endocrinology. 2023 Mar 6;14:1133566.（IF=6.005）
2. Yi Guo#*, Jinli Li#, Fengdan Hao#, Yang Yang, Hao Yang, Qiurong Chang, Pengcheng Kong, Wenqiang Liu, Xian Ting Jiao*, Xiaoming Teng* A new perspective on semen quality of aged male: the characteristics of metabolomics and proteomics. Frontiers in Endocrinology. 2023 Jan 4;13:1058250.（IF=6.005）
3. Yi Guo#, Dandan Bai#, Wenqiang Liu#, et al.Altered sperm tsRNAs in aged male contribute to anxiety-like behavior in offspring. Aging cell. 2021;20:e13466 (IF=11.005)
4.Yi Guo#, Zhijuan Cao#, Xianting Jiao, Dandan Bai, Yalin Zhang, Jing Hua,Wenqiang Liu,Xiaoming Teng* Pre-pregnancy exposure to fine particulate matter (PM2.5) increases reactive oxygen species production in oocytes and decrease litter size and weight in mice. Environmental Pollution 2021 Jan 1;268(Pt A):115858 (IF=9.998)
5. Yi Guo#, Wenqiang Liu#, Yu Wang,et al. Polarization microscopy imaging for the identification of unfertilized oocytes following short-term insemination. Fertility and Sterility.2017. 108(1):78-83 (IF=7.392)
