【承担过的主要科研项目】
主持承担国家自然科学基金项目4项、省部级/市局级等课题20余项，累计科研经费700余万元。
[Major scientific research projects undertaken]
She has undertaken 4 National Natural Science Foundation projects and more than 20 projects of the provincial/ministerial level, with a total scientific research funding of more than 7 million yuan.
1. 国家自然基金委面上项目：基于多西他赛诱导三阴性乳腺癌全细胞抗原构建特异DC纳米疫苗的研究；82073387；55万；2021.01-2024.12；在研，主持。
2. 国家自然基金委地区科学基金项目：基于新药环巴胺的微环境响应自纳米化白蛋白-CD44双靶向PD-L1单抗纳米体系在三阴性乳腺癌中的作用及机制研究；81860547；34.8万；2019.01-2022.12；在研，主持。
3. 国家自然基金委面上项目：热引导纳米化环巴胺靶向杀伤耐药性乳腺癌及作用机制；81573008；62.4 万；2016.01-2019.12；已结题，主持。
4. 国家自然青年基金委项目：基于纳米技术的联合生物治疗与化学药物治疗抗胰腺癌新策略―FAPα抗体－环巴胺－壳聚糖胶束；81201798；23万；2013.01-2015.12；已结题，主持。
【主要创新成果】
The major innovations
学术成果：
Academic achievements:
1. 申请人近期主要创新聚焦于纳米技术整合抗肿瘤研究、肿瘤免疫治疗研究。
2. 以第一作者及通讯作者发表SCI论文40余篇。其中结合跨学科纳米技术制备免疫药物递送系统增强抗PD-1/PD-L1疗效，有效抑制三阴性乳腺肿瘤生长，相关系列成果发表于《ADV MATER》、《SMALL》等国际知名杂志，单篇最高影响因子达30.849。
3. 2019年度作为项目第一完成人，以“基于纳米材料抗肿瘤药物的设计合成与活性研究”及“纳米肿瘤靶向药物的构建及应用”项目分获上海市医学科技奖青年科技奖、上海市科技进步奖三等奖。2020年获上海市女医师协会第三届医树奖•临床医学科技创新奖三等奖。
4. 申请实用型专利一项（专利号: 201910791237.9）。
临床成果：
Clinical achievement
1. 联合多家二甲医院、社区医院，完成浦东新区卫计委联合攻关项目“复发转移性乳腺癌个体化精准化诊疗模型建立”，通过结题验收，在多家医院进行推广应用。
2. 作为肿瘤疫苗研发临床顾问，与国内首个部署mRNA个体化肿瘤疫苗的斯微生物合作开展个体化mRNA肿瘤疫苗临床试验2项，逐步推进晚期及术后肿瘤患者的个体化免疫治疗试验进程，将有效推动国内mRNA肿瘤疫苗发展及肿瘤精准治疗，为个体化mRNA肿瘤疫苗制剂的生产应用及临床推广带来广阔前景。
【论文发表】
以第一作者及通讯作者发表SCI论文40余篇（单篇最高影响因子: 32.086）。
Papers published
More than 40 SCI papers has been published as the first author and corresponding author (the highest impact factor of a single paper: 32.086).
1.Chen L, Zhou LL, Wang CH, Han Y, Lu YL, Liu J, Hu XC, Yao TM, Lin Y, Liang SJ, Shi S*, Dong CY*. Tumor-Targeted Drug and CpG Delivery System for Phototherapy and Docetaxel-Enhanced Immunotherapy with Polarization toward M1-Type Macrophages on Triple Negative Breast Cancers. Adv. Mater. 2019, 31, 1904997, doi:10.1002/adma. 201904997. (IF:32.086) (通讯作者)
Zhao WR, Hu XC, Li WH, Li RH, Chen JJ, Zhou LL, Qiang SF, Wu WJ, Shi S*, Dong CY*. M2-Like TAMs Function Reversal Contributes to Breast Cancer Eradication by Combination Dual Immune Checkpoint Blockade and Photothermal Therapy. Small. 2021 Feb 18, e2007051. (IF:15.153) (通讯作者)
Lulu Zhou, Jinjin Chen, Ruihao Li, Lizhen Wei, Haitao Xiong, Chunhui Wang, Keke Chai, Mengyao Chen, Zhounan Zhu, Tianming Yao, Yun Lin, Chunyan Dong* and Shuo Shi*, Metal-Polyphenol-Network Coated Prussian Blue Nanoparticles for Synergistic Ferropotosis and Apoptosis via Triggered GPX4 Inhibition and Concurrent in Situ Bleomycin Toxification, Small. 2021 Nov;17(47):e2103919. (IF:15.153) (共同通讯作者)
Hu XC, Li RH, Wu WJ, Fang K, Zhu ZN, Wang YX, Zhou LL, Chen MY, Dong CY*, and Shi S*. A Fe(III)-porphyrin-oxaliplatin(IV) nanoplatform for enhanced ferroptosis and combined therapy. Journal of Controlled Release. 2022 Jun 20;348:660-671. (IF:11.467) (共同通讯作者)
Li RH, Hu XC, Shang FJ, Wu WJ, Zhang HJ, Wang YX, Pan JW, Shi S*, and Dong CY*. Treatment of triple negative breast cancer by near infrared light triggered mild-temperature photothermal therapy combined with oxygen-independent cytotoxic free radicals. Acta Biomater. 2022 Jun 12:S1742-7061(22)00351-8. (IF:10.633) (通讯作者)
Feng L, Chen M, Li R, Zhou L, Wang C, Ye P, Hu X, Yang J, Sun Y, Zhu Z, Fang K, Chai K, Shi S, Dong C. Biodegradable oxygen-producing manganese-chelated metal organic frameworks for tumor-targeted synergistic chemo/photothermal/ photodynamic therapy. Acta Biomater. 2022 Jan; 138:463-477. (IF:10.633) (通讯作者)
Chen M, Yang J, Zhou L, Hu X, Wang C, Chai K, Li R, Feng L, Sun Y, Dong C, Shi S. Dual-Responsive and ROS-Augmented Nanoplatform for Chemo/Photodynamic/Chemodynamic Combination Therapy of Triple Negative Breast Cancer. ACS Appl Mater Interfaces. 2022 Jan 12;14(1):57-68. (IF:10.383) (共同通讯作者)
Yang JX, Wang CH, Shi S*, Dong CY*. Nanotechnologies for enhancing cancer immunotherapy. Nano Res. 2020, doi.org/10.1007/s12274-020-2904-8. (IF: 10.269) (通讯作者)
Lulu Zhou, Jinjin Chen, Yunhao Sun, Keke Chai, Zhounan Zhu, Chunhui Wang, Mengyao Chen, Wenmei Han, Xiaochun Hu, Ruihao Li, Tianming Yao, Hui Li, Chunyan Dong* and Shuo Shi*, A Self-Amplified Nanocatalytic System for Achieving "1+1+1>3" Chemodynamic Therapy on Triple Negative Breast Cancer, Journal of Nanobiotechnology, 2021 Sep 4;19(1):261. (IF:9.429) (共同通讯作者)
Liu J, Hu XC, Feng L, Lin Y, Liang SJ, Zhu ZN, Shi S*. and Dong CY*. Carbonic anhydrase IX-targeted H-APBC nanosystem combined with phototherapy facilitates the efficacy of PI3K/mTOR inhibitor and resists HIF-1 alpha-dependent tumor hypoxia adaptation. J. Nanobiotechnol., 2022, 20, 187, doi: 10.1186/s12951-022-01394-w. (IF: 9.429) (通讯作者)
Hu XC, Lu YL, Zhao WR, Sun ML, Li RH, Feng L, Yao TM, Dong CY*, Shi S*. A PDA-DTC/Cu–MnO2 nanoplatform for MR imaging and multi-therapy for triple-negative breast cancer treatment. Chem. Commun. 2021, 57(34):4158-4161. (IF:6.224) (共同通讯作者)
Ye P, Guo Z, Zhang Y, Dong C*, Li M*. Surgery Plus Chemotherapy Versus Surgery Alone for Limited-Stage Small-Cell Lung Cancer: A Population-Based Survival Outcome Analysis. Front Oncol. 2021 May 17; 11:676598. (IF: 6.244) (通讯作者)
Chen MY, Dong CY*, Shi S*, Nanoparticle-Mediated siRNA Delivery and Multifunctional Modification Strategies for Effective Cancer Therapy. Adv. Mater. Technol. 2021, 2001236. (IF: 7.848) (共同通讯作者)
Liang S, Yang J, Lin Y, Li T, Zhao W, Zhao J, Dong C. Immune Myocarditis Overlapping With Myasthenia Gravis Due to Anti-PD-1 Treatment for a Chordoma Patient: A Case Report and Literature Review. Front Immunol. 2021 Jul 8;12:682262. (IF: 8.786) (通讯作者)
Sun Y, Li Y, Shi S*, Dong C*. Exploiting a New Approach to Destroy the Barrier of Tumor Microenvironment: Nano-Architecture Delivery Systems. Molecules. 2021;26(9):2703.(IF: 4.413) (通讯作者)
Liang SJ, Sun ML, Lu YL, Shi S, Yang YT, Lin Y, Feng C, Liu J and Dong CY*. Cytokine-induced killer cells-assisted tumor-targeting delivery of Her-2 monoclonal antibody-conjugated gold nanostars with NIR photosensitizer for enhanced therapy of cancer. Journal of Materials Chemistry B, 2020, 8, 8368 – 8382. (IF:7.571) (通讯作者)
Chen JJ, Zhou LL, Wang CH, Sun YH, Lu YL, Hu XC, Chen MY, Chen L, Chai KK, Yao TM, Shi S*, Dong CY*. Multifunctional SN38-Conjugated Nanosystem for Defeating Myelosuppression and Diarrhea Induced by Irinotecan On Esophageal Cancer. Nanoscale. 2020, 12(41):21234-21247. (IF:8.307) (通讯作者)
Zhou LL, Chen L, Hu XC, Lu YL, Liu WJ, Yao TM, Dong CY*, Shi S*. A Cu9S5 nanoparticle-based CpG delivery system for synergistic photothermal-, photodynamic- and immunotherapy. Commun. Biol. 2020, doi: 10.1038/s42003-020-1070-6. (IF尚未统计) (共同通讯作者)
Wang CH, Yang JX, Dong CY*, Shi S*. Glucose oxidase related cancer therapy. Adv. Ther. 2020 (IF尚未统计)(共同通讯作者)
Feng C, Wang K, Lin Y, Song ZW, Lu YL, Liu J, Zhu DL, Li YY*, Dong CY*. Extracellular retention of a cyclopamine nanoformulation leveraging larger size and more negative charge for improved breast cancer treatment. J Mater Chem B, 2018, 6(12): 1834-1843 (IF: 7.571) (通讯作者)
Song ZW, Lin Y, Zhang X, Feng C, Lu YL, Gao Y, Dong CY*. Cyclic RGD peptide-modified liposomal drug delivery system for targeted oral apatinib administration: enhanced cellular uptake and improved therapeutic effects. International journal of nanomedicine. 2017;12:1941-1958. (IF:4.370) (通讯作者)
Song ZW, Zhang X, Lin Y, Wei YZ, Liang SJ, Dong CY*. LINC01133 inhibits breast cancer invasion and metastasis by negatively regulating SOX4 expression through EZH2. J Cell Mol Med, 2019, 23: 7554–7565 (IF:4.658) (通讯作者)
Hu X, Lu Y, Shi X, Yao T, Dong CY*, Shi S*. Integrating in situ formation of nanozyme with mesoporous polydopamine for combined chemo, photothermal and hypoxiaovercoming photodynamic therapy. Chem. Commun, 2019,55, 14785-14788 (IF: 6.164) (共同通讯作者)
Hu X, Lu Y, Zhou L, Chen L, Yao T, Liang S, Han J, Dong CY*, Shi S*. Post Syntheses Strategy to Integrate Porphyrinic Metal-Organic Frameworks with CuS NPs for Synergistic Enhanced Photo-therapy. J. Mater. Chem. B, 2020, DOI: 10.1039/C9TB02597A. (IF: 5.047) (共同通讯作者)
Dong HQ, Dong CY, Ren TB, Li YY, Shi DL. Surface-engineered graphene-based nanomaterials for drug delivery. Journal of biomedical nanotechnology. 2014;10:2086-106. （IF:5.068）（并列第一作者）
Zhu HY, Dong CY, Dong HQ, Ren TB, Wen XJ, Su JS, Li YY. Cleavable PEGylation and hydrophobic histidylation of polylysine for siRNA delivery and tumor gene therapy. ACS applied materials & interfaces. 2014;6:10393-407. （IF:6.723）（并列第一作者）
Cai XJ, Dong CY, Dong HQ, Wang GM, Pauletti GM, Pan XJ, Shi DL. Effective gene delivery using stimulus-responsive catiomer designed with redox-sensitive disulfide and acid-labile imine linkers. Biomacromolecules. 2012;13:1024-34. （IF: 5.738）（并列第一作者）
Feng C, Chen L, Lu YL, Liu J, Liang SJ, Lin Y, Li YY*, Dong CY*. Programmable Ce6 delivery via cyclopamine based tumor microenvironment modulating nano-system for enhanced photodynamic therapy in breast cancer. Front. Chem., 2019; 7, 853 (IF: 3.782) (通讯作者)
Zhu DL, Zhang X, Lin Y, Liang SJ, Song ZW*, Dong CY*. MT1JP inhibits tumorigenesis and enhances cisplatin sensitivity of breast cancer cells through competitively binding to miR-24-3p. Am J Transl Res. 2019; 11(1): 245–256. (IF:3.061) (通讯作者)
Feng C, Zhu DL, Chen L, Lu YL, Liu J, Kim NY, Liang SJ, Zhang X, Lin Y, Ma YB*, Dong CY*. Targeted Delivery of Chlorin e6 via Redox Sensitive Diselenide-Containing Micelles for Improved Photodynamic Therapy in Cluster of Differentiation 44-Overexpressing Breast Cancer. Front Pharmacol. 2019; 10: 369. (IF: 3.845) (通讯作者)
Lu YL, Ma YB, Feng C, Zhu DL, Liu J, Chen L, Liang SJ*, Dong CY*. Co-delivery of Cyclopamine and Doxorubicin Mediated by Bovine Serum Albumin Nanoparticles Reverses Doxorubicin Resistance in Breast Cancer by Down-regulating P-glycoprotein Expression. Journal of Cancer. 2019; 10(10): 2357–2368. (IF: 3.249) (通讯作者)
Liu J, Song ZW, Feng C, Lu YL, Zhou Y, Lin Y, Dong CY*. The long non-coding RNA SUMO1P3 facilitates breast cancer progression by negatively regulating miR-320a. Am J Transl Res, 2017; 9(12): 5594–5602. (IF:3.061) (通讯作者)
Song ZW, Feng C, Lu YL, Gao Y, Lin Y, Dong CY*. Overexpression and biological function of MEF2D in human pancreatic cancer. Am J Transl Res. 2017; 9(11):4836-4847. (IF:3.061) (通讯作者)
Song Z, Zhang X, Ye XJ, Feng C, Yang G, Lu YL, Lin Y, Dong CY*. High Expression of Stromal Cell-Derived Factor 1 (SDF-1) and NF-kappaB Predicts Poor Prognosis in Cervical Cancer. Medical science monitor: international medical journal of experimental and clinical research. 2017;23:151-7. (IF:1.894) (通讯作者)
Song Z, Lu YL, Zhang X, Wang HP, Han JY, Dong CY*. Novel curcumin-loaded human serum albumin nanoparticles surface functionalized with folate: characterization and in vitro/vivo evaluation. Drug design, development and therapy. 2016;10:2643-9. (IF:2.935) (通讯作者)
Song Z, Shao C, Feng C, Lu YL, Gao Y, Dong CY*. Association of glutathione S-transferase T1, M1, and P1 polymorphisms in the breast cancer risk: a meta-analysis. Ther Clin Risk Manag. 2016;12:763-9. (IF:1.995) (通讯作者)
Song ZW, Gao Y, Ye XJ, Zhang X, Yang G, Feng C, Lu YL； Dong CY*. Increased expression of PDGF-BB predicts metastasis and poor prognosis in ovarian cancer patients. International journal of clinical and experimental pathology. 2016;9:5487-92. (IF:1.396) (通讯作者)
Song ZW, Lin Y, Ye XJ, Feng C, Lu YL, Yang G, Dong CY*. Expression of IL-1 alpha and IL-6 is Associated with Progression and Prognosis of Human Cervical Cancer. Med Sci Monitor. 2016;22:4475-81. (IF:1.894) (通讯作者)
Song ZW, Lin Y, Zhang X, Ye XJ, Yang G, Feng C, Lu YL, Dong CY*. Expression of FAP is correlated with clinical prognosis in ovarian cancer patients. International journal of clinical and experimental medicine. 2016;9:11379-84. (IF:0.833) (通讯作者)
Feng C, Li XY, Zhang XM, Zhang X, Gao Y, Dong CY*. RGD-modified liposomes enhance efficiency of aclacinomycin A delivery: evaluation of their effect in lung cancer. Drug design, development and therapy. 2015;9:4613-20. (IF: 2.935) (通讯作者)
Li YY, Chen YQ, Dong HQ, Dong CY*. Supramolecular, prodrug-based micelles with enzyme-regulated release behavior for controlled drug delivery. Medchemcomm. 2015;6:1874-81. (IF:2.342) (通讯作者)
Dong HQ, Dong CY, Xia WJ, Li YY, Ren TB. Self-assembled, redox-sensitive, H-shaped pegylated methotrexate conjugates with high drug-carrying capability for intracellular drug delivery. Medchemcomm. 2014;5:147-52 （IF:2.342）（并列第一作者）
Chu M, Dong CY, Zhu HY, Cai XJ, Dong HQ, Ren TB, Li YY. Biocompatible polyethylenimine-graft-dextran catiomer for highly efficient gene delivery assisted by a nuclear targeting ligand. Polym Chem-Uk. 2013;4:2528-39. （IF:4.927）（并列第一作者）
Li DL, Dong CY*, Gao Y. A simple and sensitive HPLC-UV method for the determination of swainsonine in rat plasma and its application in a pharmacokinetic study. Arzneimittel-Forschung. 2012;62:209-12. (IF:0.693) (通讯作者)
Dong HQ, Dong CY, Feng Y, Ren TB, Zhang ZH, Li L, Li YY. Engineering of peglayted camptothecin into core-shell nanomicelles for improving solubility, stability and combination delivery. Medchemcomm. 2012;3:1555-1561.（IF: 2.342）（并列第一作者）
