全麻机制 Mechanism of general anesthesia

慢性瘙痒的神经环路机制

The neural circuit mechanism of chronic itch

围术期神经认知紊乱

Perioperative neurocognitive disorders

赵璇，主任医师，博士生导师。现任上海市第十人民医院麻醉科主任，中华医学会麻醉学分会人工智能组副组长，中国神经科学学会麻醉与脑功能分会常务委员，上海医学会麻醉科专科分会疼痛学组副组长，中国女医师协会麻醉专业委员会委员，国际麻醉学与复苏杂志编辑委员会特邀编委。

Director of Anesthesiology department，Shanghai 10th People’s Hospital; Deputy head of Artificial Intelligence Group, Chinese Society of Anesthesiology; Standing Member, Branch of Anesthesia and Brain Function, Chinese Society of Neuroscience; Deputy head of Pain Group, Anesthesiology Branch, Shanghai Medical Association; Member of Anesthesia Professional Committee of Chinese Women Doctors Association; Guest Editor, International Journal of Anesthesiology and Resuscitation.

主要研究方向为全身麻醉机制，感觉异常的神经机制和术后认知功能障碍的发病机制。本人及团队主持了多项国家级，省部级项目，以通讯作者或第一作者在Neuroscience Bulletin，Molecular Brain等杂志发表论文30余篇。

The research interests include the mechanism of general anesthesia, the neural mechanism of paresthesia and postoperative cognitive dysfunction. Our team have presided over a number of national and provincial projects, and published more than 30 papers in journals such as Neuroscience Bulletin and Molecular Brain as corresponding author or first author.

1. Tao Zhang# , Tingting Zhang#, Xiaoyin Niu#, Lantao Li, Jiaji Gu, Minghui Chen*, Xuan Zhao*(赵璇). Femoral nerve block using lower concentration ropivacaine preserves quadriceps strength while providing similar analgesic effects after knee arthroscopy. Knee Surg Sports Traumatol Arthrosc 2023, Aug 28 online.

2. Zhang TT#, Guo SS#, Wang HY#, Jing Q, Yi X, Hu ZH, Yu XR, Xu TL, Liu MG*, Zhao X*(赵璇). An anterior cingulate cortex to midbrain projection controls chronic itch. Neuroscience Bullet, 2023; 39(5): 793-807.

3. Zhang TT#, Wang YY#, Xia Q#, Tu ZY, Sun JJ, Jing Q, Chen P, Zhao X*(赵璇). Propofol Mediated Protection of the Brain From Ischemia/Reperfusion Injury Through the Regulation of Microglial Connexin 43. Front Cell Dev Biol 2021; 8(9): 1-11.

4. Xu DJ#, Wang B#, Zhao X#(赵璇), Zheng Y, Du JL and Wang YW*. General anesthetics protects against cardiac arrest-induced brain injury by inhibiting calcium wave propagation in zebrafish. Mol Brain 2017; 10(1): 44-53.

5. Chen C#, Shen FY#, Zhao X#(赵璇), Zhou T, Xu DJ, Wang ZR and Wang YW*. Low-dose sevoflurane promotes hippocampal neurognesis and facilitates the development of dentate gyrus-dependent learning in neonatal rats. ASN Neuro 2015; 7(2): 1-13.

6. Zhang TT#, Shen FY#, Ma LQ, Wen W, Wang B, Peng YZ, Wang ZR, Zhao X*(赵璇). Potentiation of synaptic transmission in Rat anterior cingulate cortex by chronic itch. Mol Brain 2016; 9(1): 73-81.

7. Zhang XY#, Shen FY#, Xu DJ and Zhao X*(赵璇). A lasting effect of postnatal sevoflurane anesthesia on the composition of NMDA receptor subunits in rat prefrontal cortex. Int J Dev Neurosci 2016; 54: 62-69.

8. Yang ZJ#, Wang YW, Li CL, Ma LQ and Zhao X*(赵璇). Pre-treatment with a Xingnaojing preparation ameliorates sevoflurane-induced neuroapoptosis in the infant rat striatum. Mol Med Rep 2015; 11(3): 1615-1622.

9. Chen ZY#, Shen FY#, Jiang L#, Zhao X (赵璇), Shen XL, Zhong W, Liu S, Wang ZR and Wang YW*. Attenuation of Neuropathic Pain by Inhibiting Electrical Synapses in the Anterior Cingulate Cortex. Anesthesiology 2016; 124(1): 169-183.