1. 围术期神经认知功能紊乱；Perioperative Neurocognitive Disorder

2. 脓毒症相关认知功能障碍；Sepsis-related Cognitive Dysfunction

1.中华医学会麻醉学分会青年委员会，委员（Member of Youth group, Chinese Society of Anesthesiology）

2.中国心胸血管麻醉学会创新与推广分会，常务委员（Standing Committee Member of Committee of Innovation and Promotion, Chinese Society of Cardiothoracic and Vascular Anesthesiology）

3.中国心胸血管麻醉学会人工智能麻醉分会，委员（Member of Artificial Intelligence Anesthesia Committee, Chinese Society of Cardiothoracic and Vascular Anesthesiology）

4.中国医疗保健国际交流促进会区域阻滞与疼痛医学分会，委员（Member of Regional Blocking and Pain Branch, China International Exchange and Promote Association for Medical and Healthcare)

5.中国医疗保健国际交流促进会麻醉围术期医学分会，委员(Member of Perioperative Medicine Branch of Anesthesia ,China International Exchange and Promotive Association for Medical and Healthcare)

6.中国超声工程学会麻醉与疼痛超声委员会，委员（Member of Committee on Ultrasound of Anesthesia and Pain, Chinese Association of Ultrasound in Medicine and Engineering)

7.中国医学模拟教学联盟气道管理专业委员会，委员 (Member of Airway Management Professional Committee, Chinese Medical Stimulation Teaching Alliance)

8.中国非公立医疗机构协会麻醉专业委员会，委员（member of Anesthesia Committee, Chinese Non-government Medical Institutions Assosiation）

9.上海市医师协会麻醉科医师分会，委员（member of the Anesthesiologist Branch of Shanghai Medical Doctor Association）

10.上海中医药学会围术期医学分会，委员（member of Perioperative Medicine Committee，Shanghai Association of Chinese Medicine）

11.中国中西医结合麻醉学会针药复合学术委员会，委员（board member, Academic Committee of Acupuncture and Medicine of Chinese Society of Integrative Anesthesiology）

12.上海市中西医结合麻醉学会科学学组，委员（member of Scientific group of Shanghai Society of Integrative Anesthesiology）

哈佛5848vip威尼斯电子游戏附属麻省总院访问学者，5848vip威尼斯电子游戏附属上海市第四人民医院麻醉与围术期医学科主任（国家临床重点专科），上海市优秀学术带头人（青年），上海市东方英才（青年）、首届“上海好医生”、上海市银蛇奖三等奖。主要研究方向是老年麻醉与围术期管理和脑保护，主持国家自然科学基金等项目15项，参与国自然重大项目、国自然国际合作重点项目等6项。以通讯/第一作者在国际知名期刊BJA，Angew. Chem. Int. Ed等发表SCI论文25篇，最高IF 16.6，总IF 141.799，授权实用新型专利5项。Anesthesiology and Perioperative Science学术编委、教育部学位论文评审专家。获得5848vip威尼斯电子游戏优秀教师，培养博士后/博硕士研究生17人次，其中1人获得上海市优秀毕业生。

一、近年主持的主要科研项目及人才计划：

上海市优秀学术带头人（Shanghai excellent academic leader of Shanghai Science and Technology Commission）：基于海马小胶质细胞蛋白乳酸化修饰探究术后谵妄的发生机制，40万，23XD1422900，2023/05/01-2026/04/30，在研，主持。

1.国家自然科学基金面上项目（National Natural Scientific Foundation of China）：小胶质细胞MD2调控突触稳定性介导术后认知功能障碍的机制研究，52万，82271223，2023/01/01- 2026/12/31，在研，主持。

2.上海市自然科学基金项目（Natural Science Foundation of Shanghai）：能量相关CircRNA-Sobp/miR-672-3p/ATPIF1信号轴调控线粒体凋亡在七氟烷诱导术后认知功能障碍中的作用及机制研究，20万，20ZR1442900，2020/07/01-2023/06/30，已结题，主持。

3.2021年度上海市第四人民医院科研启动经费（Scientific Research Start-up Fund from Shanghai Fourth People’s Hospital）：NMDAR/FOXO3A/ circRNA- Sobp通路在吸入麻醉药麻醉作用及术后认知功能障碍中的共有机制研究，sykyqd01901，2021.02- 2027.01，100万，在研，主持。

4.2021年度上海市第四人民医院学科助推计划（新技术重点项目）（Subject Enhancement Programme of Shanghai Fourth People’s Hospital ）：椎旁神经阻滞复合骶管麻醉在经皮肾镜激光碎石中的应用，2021.10.01-2023.09.30，SY-XKZT-2021-2001，10万，在研，主持。

5.国家自然基金青年项目（Youth Project of National Natural Scientific Foundation of China )：ATPIF1/ATP合酶在异氟烷致秀丽线虫全身损伤中的机制研究，20万，81600921，2017/01-2019/12, 已结题，主持。

6.上海市自然科学基金项目（Natural Science Foundation of Shanghai）：ATP合酶c-亚基环解耦联通道介导吸入麻醉药神经毒性作用的分子机制，20万，16ZR1426400，2016/07/01-2019/06/30，已结题，主持。

7.上海市卫计委青年项目（Shanghai Health and Family Planning Committee）：ATP合酶c-亚基环解耦联通道在吸入麻醉药引起术后认知功能障碍中的作用，2万，20154Y0011，2016/01-2018/12，已结题，主持。

二、近年发表的主要论文：

1.Jiang Li#, Yayun Shi#, Chenyang Qi#, Bowen Zhang, Xiwen Xing, Yuliang Li*, Tongdan Chen, Xingnuo Mao, Zhijun Zuo, Xiaoli Zhao, Zhenghui Pan, Libo Li, Xiaowei Yang* and Cheng Li*. Angew. Chem. Int. Ed., 2023, DOI: 10.1002/anie.202309918.(通讯作者，IF: 16.6，JCR 1区，VIP论文)

2.Silu Cao#, Jinxuan Tang #, Miaomiao Fei#, Qi Jing, Fanbing Meng, Meixian Zhang, Qidong Liu*, Hui Zhang*, Cheng Li*. Front.Immunol. 2023, DOI: 10.3389/fimmu.2023.1238774 (通讯作者，IF: 7.3，JCR 1区)

3.Xiaoxiao Sun#, Meixian Zhang#, Hui Zhang, XueJie Fei, Gang Bai*, Cheng Li*. Efficacy and safety of ciprofol for long-term sedation in patients receiving mechanical ventilation in ICUs: a prospective, single-center, double-blind, randomized controlled protocol. Front Pharmacol.  2023 Aug 21;14:1235709. doi: 10.3389/fphar.2023.1235709. eCollection 2023.(通讯作者， IF：5.6，JCR 1区)

4.Silu Cao#, Yiling Wu#, Zilong Gao#, Jinxuan Tang, Lize Xiong, Ji Hu*, Cheng Li*. Automated phenotyping of postoperative delirium-like behaviour in mice reveals the therapeutic efficacy of dexmedetomidine. Commun Biol 6, 807 (2023). https://doi.org/10.1038/s42003-023-05149-7 (通讯作者，IF: 5.9，JCR 1区)

5.Qi Jing , Lize Xiong* , Cheng Li* , The prevalence of olfactory dysfunction with Omicron has decreased in Asia, similar to Western countries – Author’s reply, International Journal of Infectious Diseases (2023), doi: https://doi.org/10.1016/ j.ijid.2023.03.041. (通讯作者，IF: 8.4， JCR 1区)

6.Fei Miaomiao#, Qin Wendong#, An Guanghui, Li Dujian, Li Cheng* and Xiong Lize*. Comparison of paravertebral block vs. general anesthesia for percutaneous nephrolithotomy: A retrospective study. Front. Med. 10:1081530. doi: 10.3389/fmed.2023.1081530. (共通讯作者，IF:3.9，JCR 2区)

7.Jian Song#, Qi Jing#, Enzhao Zhu#, Qidong Liu, Miaomiao Fei, Hui Zhang, Guanghui An, Silu Cao, Jinxuan Tang, Guanghui Xu, Yi Liu, Zisheng Ai, Yingna Tao*, Cheng Li*, Lize Xiong*. Alterations in smell or taste in individuals infected with SARS-CoV-2 during periods of Omicron variant dominance. International Journal of Infectious Diseases. International Journal of Infectious Diseases 128 (2023) 278–284. Published: January 15, 2023, DOI: https://doi. org/10.1016/j.ijid.2023.01.017 (共通讯作者，IF: 8.4， JCR 1区)

8.Xiaoru Sun#, HuitongRuan# *, Qidong Liu, Silu Cao, Qi Jing, Yaru Xu, LizeXiong*, Wenguo Cui*, Cheng Li*.Targeted regulation of neuroinflammation via nanobiosignaler for repairing the central nerve injuries. Nano Res. 25 Nov. 2022, online, DOI：https://doi.org/10.1007/s12274-022-5143-3.(通讯作者，IF: 9.9， JCR 1区)

9.Hui Zhang#, Silu Cao#, Yaru Xu, Xiaoru Sun, Miaomiao Fei, Qi Jing, Xiaodong Xu,Jinxuan Tang, Bing Niu* and Cheng Li*. Landscape of Immune Compartment in Entorhinal Cortex of Alzheimerʼs Disease. Front. Pharmacol., 28 September 2022 Sec. Neuropharmacology https://doi.org/10.3389/fphar.2022. 941656. (通讯作者，IF:5.6，JCR 1区)

10.Yiling Fang#, Yaru Xu#, Silu Cao, Xiaoru Sun, Hui Zhang, Qi Jing, Li Tian* and, Cheng Li*. Incidence and Risk Factors for Hypoxia in Deep Sedation of Propofol for Artificial Abortion Patients. Front Med (Lausanne) 2022; 9: 763275. Published online 2022 Apr 27. doi: 10.3389/fmed.2022.763275. (通讯作者，IF:3.6，JCR 2区)

11.Qidong Liu#,Huitong Ruan#,Zhihao Sheng#,Xiaoru Sun,Siguang Li*,Wenguo Cui* and Cheng Li*. Nanoantidote for repression of acidosis pH promoting COVID-19 infection. View 2022. First published: 01 May 2022; https://doi.org/ 10.1002/VIW.20220004 (通讯作者，IF:8.6，JCR 1区)

12.Yiling Fang#, Qi Jing#, Silu Cao, Xiaoru Sun,  Hui Zhang,  Li Tian*  and Cheng Li*. The Effect of Relaxation Therapy on Hypoxia During Intravenous Propofol Anesthesia in Patients With Pre-operative Anxiety: A Prospective Randomized Controlled Trial. Front Med (Lausanne) 2022; 9: 797337. Published online 2022 Mar 15. doi: 10.3389/fmed.2022.797337. (通讯作者，IF:3.6，JCR 2区)

13.Hui Zhang#, QidongLiu#, XiaoruSun, Yaru Xu, Yiling Fang, Silu Cao, Bing Niu*, Cheng Li*. Integrated Bioinformatic and Machine Learning Algorithms analysis highlights related pathways and genes associated with Alzheimer's disease. Current Bioinformatics, 04 February, 2022;17(3):284-295. DOI: 10.2174/1574893617666211220154326（通讯作者，IF:4.0，JCR1区 ）

14.Xiaoru Sun#, Hui Zhang# , Dongdong Yao , Yaru Xu, Qi Jing, Silu Cao, Li Tian*, Cheng Li*. Integrated Bioinformatics Analysis Identifies Hub Genes Associated with Viral Infection and Alzheimer’s Disease. J Alzheimers Dis. 2022;85(3):1053-1061. doi: 10.3233/JAD-215232.（通讯作者，IF:4.0，JCR 1区）

15.Yaru Xu#, Ge Gao#, Xiaoru Sun, Qidong Liu*,Cheng Li*. ATPase Inhibitory Factor 1 is critical for regulating sevoflurane-induced microglial inflammatory responses and caspase-3 activation. Front. Cell. Neurosci.15 December 2021.https://doi.org/10.3389/fncel.2021.770666（通讯作者，IF:6.147，JCR 2区）

16.Shaocheng Wang#, Chaoli Hu#, Tingting Zhang, Xuan Zhao*, Cheng Li*. Comparison of cricothyroid membrane puncture anesthesia and topical anesthesia for awake fiberoptic intubation: a double-blinded randomized controlled trial. Front Med (Lausanne). 2021 Nov 16; 8: 743009.(通讯作者，IF:5.058，JCR 1区)

17.Xiaoru Sun#, Tao Chang#, Yaru Xu , Qi Jing , Silu Cao , Li Tian*, Cheng Li*. Effects of different doses of cisatracurium on intraoperative nerve monitoring in thyroid surgery: a randomised controlled trial. Br J Anaesth. 2021 Aug;127(2):e67-e69. (通讯作者, IF:11.719, JCR 1区)

18.Qi Jing#, Hui Zhang#, XiaoruSun, Yaru Xu, Silu Cao, YilingFang, Xuan Zhao*, Cheng Li*. Comprehensive analysis identifies hub genes and associated drugs in Alzheimer’s disease. BioMed Research International.2021 Jan 9; 2021:8893553. (通讯作者, IF:3.246 , JCR2区)

19.Lingling Zhang#, Tao Chang#, Yaru Xu, Qi Jing, Xuan Zhao* and Cheng Li*. Epidural anesthesia with low concentration ropivacaine and sufentanil for percutaneous transforaminal endoscopic discectomy: a randomized controlled trial.Front Med (Lausanne). 2020 Jul 31;7:362.(通讯作者，IF:5.091，JCR 1区)

20.Chen D, Fang Y, Zhang L, Niu X, Sun X, Niu X, Zhao X, Li C*. Hydrogen sulfide ameliorates isoflurane-induced cognitive impairment in mice: Implication of caspase-3 activation. Trop J Pharm Res. 2020; 19(4):773-780. (通讯作者，IF: 0.533， JCR 3区)

21.Li M#, Liu Z#, Lin F, Wang H, Niu X, Ge X, Fu S, Fang L, Li C*. End-tidal carbon dioxide monitoring improves patient safety during propofol-based sedation for breast lumpectomy: a randomised controlled trial. Eur J Anaesthesiol. 2018 Nov; 35(11):848-855.(通讯作者，IF: 4.14，JCR 1区)

三、获得的荣誉

2023年9月 “上海市东方英才（青年）”；

2023年8月 “上海好医生”；

2023年5月 “上海市优秀学术带头人”；

2023年1月 2022年度虹口区事业单位工作人员嘉奖；

2023年 院“优秀中层干部”；

2022年 5848vip威尼斯电子游戏“最美师德师优秀教师”；

2022年1月 2021年度虹口区事业单位工作人员嘉奖；

2022年 上海卫生系统“首届恒杰专项技术扶持计划”；

2022年 院“优秀中层干部”；

2021年 上海市卫生系统银蛇奖（三等奖）；

2020年 院优秀临床研究专员；

2019年 2018年度十院第二届“匠心工程”成长计划；

2018年 2017年度院“优秀共产党员”；